Results 41 to 50 of about 189,459 (306)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Analytical study on the composite behavior of rectangular CFST columns under combined compression and torsion

Case Studies in Construction Materials, 2022
In this paper, a total of 44 rectangular CFST column finite element models are established and verified. The effect of loading path, the working mechanism and the constraint interaction of rectangular CFST column under compression-torsion loading are ...
En Wang, Faxing Ding, Liping Wang, Yangbo Chen, Shijing Sheng, Jingtao Shen, Qitao Lin   +6 more
doaj   +1 more source

FE analysis on tube hydroforming of small diametr ZM21 magnesium alloy tube [PDF]

, 2019
Tube hydroforming (THF) is one of the plasticity processing methods. Tubular parts, for instance automotive components are expanded by forces such as internal pressure and axial compression in order to deform an objective shape.
Furushima, T., Ito, Y., Miyagawa, T., Yamada, R., Yasui, H., Yoshihara, S.   +5 more
core  

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Experimental Study on the Seismic Performance of Insulated Single-Sided Composite Shear Walls under Different Shear Spans and Axial Compression Ratios

Advances in Civil Engineering
The new insulated single-sided composite shear wall (NISCSW) composition involves setting a precast wall panel on one side and an insulation panel on the other side, with a middle cavity for casting concrete.
Qiang Sun, Shoufeng Zhang, Ke Liu, Xinyi Wu, Guowei Zhang, Bei Cheng   +5 more
doaj   +1 more source

Experimental investigation on the static shear stiffness of an immersion joint [PDF]

, 2016
The static shear stiffness of an immersion joint subjected to combined compression and shear forces is investigated by experiments in a test set-up. To explore the performance of the immersion joint, the compression-shear loads, which are applied on a ...
Taerwe, Luc, Xiao, Wenhao, Yuan, Yong
core   +1 more source

Experimental investigation of the elastoplastic response of aluminum silicate spray dried powder during cold compaction [PDF]

, 2014
Mechanical experiments have been designed and performed to investigate the elasto-plastic behaviour of green bodies formed from an aluminum silicate spray dried powder used for tiles production.
Bigoni, D., Bosi, F., Cocquio, A., Corso, F. Dal, Gei, M., Piccolroaz, A.   +5 more
core   +2 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Ductilityof fiber-reinforcedself-consolidatingconcreteundermulti-axial compression

, 2011
The results of 12 multi-axial compression tests performed on cylinders made of self-consolidating concrete, plain (SCC) and reinforced with steel fibers (FR-SCC), are presented.
Chiaia, Bernardino, Fantilli, Alessandro Pasquale, Vallini, Paolo   +2 more
core   +1 more source