Results 21 to 30 of about 48,227 (268)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Research on axial compression performance test and bearing capacity calculation method of newly assembled hollow lattice wallboard

Frontiers in Materials
With the great development of the construction industry, prefabricated building components have been greatly developed. To study the compressive performance of the new wallboard, the axial compression performance test of six full-scale new lattice ...
Yunlin Liu, Yunlin Liu, Shangwei Huo, Zhixin Wu, Dingguo Yang, Ke Ren, Jianhua Liu, Riguang Wang   +7 more
doaj   +1 more source

Seismic Behavior of Short Concrete Columns with Prestressing Steel Wires

Advances in Materials Science and Engineering, 2014
The seismic behavior of short circular reinforced concrete columns was studied by testing seven columns retrofitted with prestressing steel wire (PSW), subjected to combined constant axial compression and lateral cyclic load.
Deng Zong-Cai, Jumbe R. Daud, Li Hui
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Experimental Study on the Seismic Performance of Insulated Single-Sided Composite Shear Walls under Different Shear Spans and Axial Compression Ratios

Advances in Civil Engineering
The new insulated single-sided composite shear wall (NISCSW) composition involves setting a precast wall panel on one side and an insulation panel on the other side, with a middle cavity for casting concrete.
Qiang Sun, Shoufeng Zhang, Ke Liu, Xinyi Wu, Guowei Zhang, Bei Cheng   +5 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Research on Bearing Capacity of Angle Steel Transmission Tower Subject to Parallel Reinforcement by Fitting Channel Steel

南方能源建设, 2023
[Introduction] The existing angle steel transmission tower has been running for many years, and the structural damage leads to the reduction of service performance.
Jinghui LI, Xianghong LIU, Jiaqi WANG, Qing SUN, Donghong ZHANG   +4 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Behavior of welded gabion boxes in axial compression tests

Soils and Rocks
This article presents the results of innovative laboratory tests conducted on different types of cubic gabion boxes, each with approximate edge length of 1 m. The tests evaluated both confined and unconfined boxes subjected to compression stresses. In addition to the confinement factor, the experimental variables included the type of mesh, the presence
Gisleine Coelho Campos, Rafael Fonseca, Gelmo Chiari Costa   +2 more
openaire   +2 more sources