Results 31 to 40 of about 2,063,327 (311)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Comparative evaluation of implant designs: Influence of diameter, length, and taper on stress and strain in the mandibular segment-A three-dimensional finite element analysis

Journal of Pharmacy and Bioallied Sciences, 2019
Introduction: Success or failure of dental implants depends on the amount of stress transferred to the surrounding bone. Increased amount of loading to the bone through implant cause failure, whereas decrease in the amount of loading to the bone causes ...
Gowthama Raaj, Pulliappan Manimaran, Chandran Dhinesh Kumar, Duraisamy Sai Sadan, Mathivanan Abirami   +4 more
doaj   +1 more source

Axial Compression Prediction and GUI Design for CCFST Column Using Machine Learning and Shapley Additive Explanation

Buildings, 2022
Axial bearing capacity is the key index of circular concrete-filled steel tubes (CCFST). A hybrid PSO-ANN model consisting of an artificial neural network (ANN) optimized with particle swarm algorithm (PSO) was proposed to reliably and accurately predict
Xuerui Liu, Yanqi Wu, Yisong Zhou
doaj   +1 more source

Impact of Screw Diameter and Length on Pedicle Screw Fixation Strength in Osteoporotic Vertebrae: A Finite Element Analysis

Asian Spine Journal, 2020
Study Design Biomechanical study. Purpose To quantitatively investigate the effect of screw size on screw fixation in osteoporotic vertebrae with finite element analysis (FEA) Overview of Literature Osteoporosis poses a challenge in spinal ...
Keitaro Matsukawa, Y. Yato, Hideaki Imabayashi   +2 more
semanticscholar   +1 more source

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Correlation between axial and coronal common bile duct diameters in computed tomography: a retrospective study of 1064 patients

The Egyptian Journal of Radiology and Nuclear Medicine
Background The measurement of the common bile duct (CBD) diameter is essential for evaluating bile duct pathologies. The axial plane of computed tomography (CT) images is the established method for CBD diameter measurement.
Adisak Kasemassawachanont, Natinee Chuangsuwanich, Wanicha Lertpipopmetha, Nutthanun Panrong, Kittipott Thusneyapan, Sasima Tongsai, Napakadol Noppakunsomboon, Rathachai Kaewlai   +7 more
doaj   +1 more source

Orthogonal Analysis of Axial Bearing Capacity of Short Columns Reinforced by Circular Steel Tube and Ultra High Performance Concrete with Coarse Aggregate

Renmin Zhujiang, 2021
This paper analyzes the influence of outer diameter of steel tube, wall thickness of steel tube, steel strength and concrete strength on the axial bearing capacity of short columns reinforced by circular steel tube and ultra high performance concrete ...
TANG Jiajun, WANG Tan, LI Jiuyang
doaj  

Optic Disc-Fovea Distance, Axial Length and Parapapillary Zones. The Beijing Eye Study 2011. [PDF]

PLoS ONE, 2015
To measure the distance between the optic disc center and the fovea (DFD) and to assess its associations.The population-based cross-sectional Beijing Eye Study 2011 included 3468 individuals aged 50+ years.
Rahul Arvo Jonas, Ya Xing Wang, Hua Yang, Jian Jun Li, Liang Xu, Songhomitra Panda-Jonas, Jost Bruno Jonas   +6 more
doaj   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source