Results 41 to 50 of about 2,147,929 (306)

Exact Stiffness Matrix for Nonprismatic Beams with Parabolic Varying Depth

open access: yesJournal of Engineering, 2023
In this paper, an exact stiffness matrix and fixed-end load vector for nonprismatic beams having parabolic varying depth are derived. The principle of strain energy is used in the derivation of the stiffness matrix. The effect of both shear deformation
Musab Aied Qissab Al-Janabi
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Effect of Steel Support Cross-Section and Preloaded Axial Force on the Stability of Deep Foundation Pits

open access: yesBuildings
To investigate the effects of steel support cross-section dimensions and preloaded axial force levels on the stability of foundation pits, numerical simulations were conducted for open-cut deep foundation pits based on monitoring data from Changchun ...
Yang Jin   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Direct-Drive Conical-Rotor Permanent Magnet Synchronous Generator for Turbo-Expander, Accounting for Adaptive Equilibrium of Axial Force

open access: yesIEEE Access, 2018
The permanent magnet synchronous generator (PMSG) has been widely employed in high-speed direct-drive turbo-expander for distributed energy generation.
Jiaobao Wang   +4 more
doaj   +1 more source

Wear analysis of finger locks with different design parameters for landing gear

open access: yesScience Progress, 2020
The finger lock in the retractable actuator of the landing gear will wear during repeated unlocking and locking. Therefore, the effects of six parameters including the material of the finger lock, the length of the finger lock, the diameter of the finger
Yu Hou, Ming Zhang, Hong Nie
doaj   +1 more source

Based on Wavelet and Windowed Multi-Resolution Dynamic Mode Decomposition, Transient Axial Force Analysis of a Centrifugal Pump under Variable Operating Conditions

open access: yesEnergies, 2023
This study analyzes the transient axial force of a centrifugal pump under variable operating conditions using wavelet analysis and a novel technique called windowed multi-resolution dynamic mode decomposition (wmrDMD).
Haoqing Jiang   +3 more
doaj   +1 more source

Enhancing the Applied Force and Range of Axial Optical Tweezers

open access: yesBiophysical Reports, 2023
Axial optical tweezers provide a natural geometry for performing biomechanical assays such as rupture force measurements of protein binding. Axial traps, however, are typically weaker than their lateral counterparts requiring high laser power to maintain a well calibrated, linear restoring force.
Zheng Zhang, Joshua N. Milstein
openaire   +3 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

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