Results 61 to 70 of about 99,325 (262)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Axial force measurement for esophageal function testing
World Journal of Gastroenterology, 2009 The esophagus serves to transport food and fluid from the pharynx to the stomach. Manometry has been the "golden standard" for the diagnosis of esophageal motility diseases for many decades. Hence, esophageal function is normally evaluated by means of manometry even though it reflects the squeeze force (force in radial direction) whereas the bolus ...
Gravesen, Flemming-H +3 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Effect of an Axial Force on the Vibration of Hinged Bars [PDF]
Journal of Applied Mechanics, 1950 Abstract It can be shown that the vibration of an extensible bar, carrying no transverse load and having the ends fixed at the supports, causes an axial tensile force with a period equal to the half-period of the vibration of the bar.
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Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Sensors, 2019 : Fiber Bragg grating (FBG) sensors, which can accurately measure strain, can be integrated with rock bolts with small fingerprints. In this paper, according to the force mechanism of prestressed anchor and non-prestressed anchor, different loading modes
Xinxin Guo +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Axial force sensor for screw bolt using optical fiber grating for detection of strain
Nihon Kikai Gakkai ronbunshu, 2015 In this study, an axial force sensor was developed and evaluated for a screw bolt using optical fiber grating (FBG: fiber Bragg grating). This sensor has high tolerance to electromagnetic noise.
Hiromu IWATA +2 more
doaj +1 more source
THE AXIAL FORCE IN ALUMINIUM FOAM DRILLING
Tehnički vjesnik, 2006 Metals in foam shape, the so called metallic foams or metal foams, consist of a base metal material with a certain amount of gas bubbles dispersed throughout the body of the material. These bubbles are actually foam cavities or cells. Metal foams are low-density materials with high strength and rigidity, as well as with good damping capacity. Therefore,
Ciglar, Damir +2 more
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source