Results 71 to 80 of about 99,325 (262)

Acoustic frequency spectrum characteristics in periodic drill string under tension

Energy Science & Engineering, 2020
It is a promising measure to transmit downhole information by acoustic wave through drill string. However, the transmission distance and quality of acoustic signals in field conditions are still not satisfied because the acoustic frequency spectrum in ...
Qing Wang, Zhichuan Guan, Yongwang Liu
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Analysis of Traveling Wave and Combined Site Effect of Long-Span Upper-Bearing Concrete-Filled Steel Tubular Arch Bridge

Advances in Civil Engineering
In order to study the traveling wave effect and combined site effect of long-span steel tube concrete-filled arch bridge, a 400-m span bridge of the same type is taken as an example, and a large-mass time-history analysis method with multipoint input of ...
Zite Li, Genhui Wang, Jiang Fan, Yue Jian, Yongliang Zhang   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Investigation of the Axial Force Compensation and Deformation Control Effect of Servo Steel Struts in a Deep Foundation Pit Excavation in Soft Clay

Advances in Civil Engineering, 2019
This study presents a comparative analysis of the deformation control effect of the hydraulic servo steel struts and ordinary steel struts of a foundation pit based on the measured axial force of the steel struts, lateral wall deflection, and ground ...
Honggui Di, Huiji Guo, Shunhua Zhou, Jinming Chen, Lu Wen   +4 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Axial rotation in the lumbar spine following axial force wrench.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2010
The report presents measurements of axial rotation of lumbar motion segments (L1/L2, L3/L4, L4/L5), particularly with small angles of rotation (in the range of +/-1 degrees) following axial force wrenches. The investigation focussed on determining the influence of geometrically varying configurations in axial wrench (consisting of axial torque and ...
Wachowski, Martin Michael, Hubert, Jan, Hawellek, Thelonius, Mansour, Michael, Dorner, J., Kubein-Meesenburg, Dietmar, Fanghanel, J., Raab, Bjoern-Werner, Dumont, B. C., Nagerl, H.   +9 more
openaire   +2 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source