Results 61 to 70 of about 472,137 (304)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Análisis de la fuerza axial en un transportador de sinfín // Analysis of axial force in a screw conveyor.

Ingeniería Mecánica, 1999
Durante el movimiento de un material en un transportador de sinfín surge una fuerza en dirección axial que influye en laselección de uno de los cojinetes de apoyo del equipo.
F. Aguilar Parés
doaj  

Experimental Determination of Changing the Axial Force in the Bolts of the Clamping Sleeve Under Its Axial Load

Journal of Mechanical Engineering, 2021
This paper deals about experimental determination of changing the axial load in the bolts of the clamping sleeve under its axial load. Inspiration for this experiment was FEM analysis clamping sleeve in Ansys workbench.
Lukáš Hruzík, Jiří Struž, Květoslav Kaláb   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Nonlinear static and dynamic analysis of mixed cable elements [PDF]

, 2017
This paper presents a family of finite elements for the nonlinear static and dynamic analysis of cables based on a mixed variational formulation in curvilinear coordinates and finite deformations.
Crusells Girona, Miquel, Filippou, Filip C., Taylor, Robert L.   +2 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Numerical Calculation and Experimental Study of the Axial Force of Aero Fuel Centrifugal Pumps

Applied Sciences
Axial force is one of the important factors affecting the life and reliability of centrifugal pumps. Based on the SST turbulence model, the unsteady internal flow field of an aero fuel centrifugal pump under various working conditions was analyzed by ...
Shebin Yan, Yinhui Kan, Xin Li, Lingfei Xiao, Zhifeng Ye   +4 more
doaj   +1 more source

Testing Mechanical Properties of Rock Bolt under Different Supports Using Fiber Bragg Grating Technology

Sensors, 2019
: Fiber Bragg grating (FBG) sensors, which can accurately measure strain, can be integrated with rock bolts with small fingerprints. In this paper, according to the force mechanism of prestressed anchor and non-prestressed anchor, different loading modes
Xinxin Guo, Bo Wang, Zhenwang Ma, Zhenyu Wang   +3 more
doaj   +1 more source

Axisymmetric force-free magnetosphere of a pulsar. I. The structure close to the magnetic axis

, 2012
The stationary axisymmetric force-free magnetosphere of a pulsar is studied analytically. The pulsar equation is solved in the region close to the magnetic axis. Proceeding from linearization of the current function in the axial region, we find the axial
Bai, Beskin, Contopoulos, Contopoulos, Goldreich, Gradshteyn, Kalapotharakos, Kalapotharakos, Kalapotharakos, Komissarov, Li, Lyubarsky, McKinney, Michel, Michel, Michel, Okamoto, S. A. Petrova, Scharlemann, Shibata, Spitkovsky, Timokhin, Timokhin, Yuki   +23 more
core   +1 more source