Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Ocular axial length changes following trauma: Blunt versus penetrating
TNOA Journal of Ophthalmic Science and Research, 2019 Aims: This study aims to analyze the effect of penetrating and blunt trauma on ocular axial length. Settings and Design: This is a retrospective study.
Madhu Shekhar +2 more
doaj +1 more source
Forced convection and flow boiling with and without enhancement devices for top-side-heated horizontal channels [PDF]
The effect of enhancement devices on flow boiling heat transfer in coolant channels, which are heated either from the top side or uniformly was studied.
Boyd, Ronald D., Sr., Turknett, Jerry C.
core +1 more source
Dynamical modelling of the motorised momentum exchange tether incorporating axial elastic effects [PDF]
, 2007 A discretised planar tether model is proposed for the Motorised Momentum Exchange Tether (MMET) in which axial elasticity is accommodated. The model uses a generalised co-ordinate defining angular motion of the tether about its centre of mass, as it ...
Cartmell, M., Chen, Y.
core
From axial to road-centre lines: a new representation for space syntax and a new model of route choice for transport network analysis [PDF]
, 2007 Axial analysis is one of the fundamental components of space syntax. The space syntax community has suggested that it picks up qualities of configurational relationships between spaces not illuminated by other representations.
Turner, A.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Royal College of Ophthalmologists’ National Ophthalmology Database study of cataract surgery: report 8, cohort analysis of the relationship between intraoperative complications of cataract surgery and axial length [PDF]
, 2022 Alexander Day +4 more
openalex +1 more source