Results 51 to 60 of about 220,547 (261)

Ocular axial length and its associations: A systematic review

African Vision and Eye Health
Background: Axial length is key in determining the underlying cause of refractive errors, including myopia. It is essential for assessing myopic progression or risk in patients. Aim: To systematically evaluate associations between ocular axial length and
Andrew T. Chikara, Tanya Evans, Solani D. Mathebula   +2 more
doaj   +1 more source

Axial Length Correction in Evaluation of Refractive Predictability and Biometry Agreement [Letter]

Clinical Ophthalmology, 2023
Ferdinando Cione, Gerardo La Padula, Antonio Formicola Eye Unit, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno, ItalyCorrespondence: Gerardo La Padula, Eye Unit, Department of Medicine, Surgery ...
Cione F, La Padula G, Formicola A
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Refractive Results and Complications of Lensectomy in Simple Extreme Microphthalmos Cases

Türk Oftalmoloji Dergisi
Objectives: To evaluate the refractive outcomes, changes in intraocular pressure (IOP) and anterior chamber depth (ACD), and postoperative complications following lensectomy for angle-closure in cases of simple extreme microphthalmos.
Gülşah Gümüş Akgün, Neşe Alagöz, Ece Doğruel, Nilay Kandemir Beşek, Ahmet Kırgız, Erdem Erdoğdu, İhsan Çakır, Çiğdem Altan, Tekin Yaşar   +8 more
doaj   +1 more source

Axial Length Correction in Evaluation of Refractive Predictability and Biometry Agreement [Response to Letter]

Clinical Ophthalmology, 2023
Bjørn Gjerdrum,1 Kjell Gunnar Gundersen,1 Christian Nilsen,1,2 Morten Gundersen,1,2 Per Jensen1,2 1Ifocus Eye Clinic, Stavanger, Norway; 2Faculty of Health Sciences, Oslo Metropolitan University, Oslo, NorwayCorrespondence: Bjørn Gjerdrum ...
Gjerdrum B, Gundersen KG, Nilsen C, Gundersen MM, Jensen P   +4 more
doaj  

Magnification Effect of Foveal Avascular Zone Measurement Using Optical Coherence Tomography Angiography

Biomedicine Hub, 2020
Purpose: The aim of this study was to evaluate the foveal avascular zone (FAZ) of healthy subjects and examine the magnification effect. Methods: A total of 33 healthy volunteers were enrolled and all subjects were eligible for analysis.
Mika Suda, Yuji Yoshikawa, Gaku Terauchi, Soiti Matsumoto, Takuhei Shoji, Kei Shinoda, Atsushi Mizota, Yoshiharu Kobayashi   +7 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Does Chin-Throat Length Relate to Oropharyngeal Volume, Minimum Axial Area, and Polysomnographic Indices?

Biomedical Sciences and Clinical Medicine
OBJECTIVE To evaluate the correlation between chin-throat length and oropharyngeal volume, minimum axial area, and polysomnographic indices in patients undergoing orthodontic treatment.
Wachira Tantirittiporn, Nuntigar Sonsuwan, Warit Powcharoen, Dhirawat Jotikasthira, Thanapat Sastraruji, Pathaweex Pathawee Khongkhunthian, Kachaphol Kuharattanachai, Kanich Tripuwabhrut   +7 more
doaj   +1 more source