Results 31 to 40 of about 220,547 (261)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Prediction of myopia based on biometric parameters of 500,000 children and adolescents aged 3–18 years

Frontiers in Public Health
PurposeTo explore the validity and significance of the axial length/corneal radius (AL/CR) Ratio for myopia prediction in children of all ages.MethodsBetween 2020 and 2022, 509,530 children and adolescents aged 3–18 years were sampled in Chengdu City ...
Siyu Chen, Siyu Chen, Siyu Chen, Siyu Chen, Jingyu Mu, Jingyu Mu, Jingyu Mu, Jingyu Mu, Xiyue Tan, Xiyue Tan, Xiyue Tan, Xiyue Tan, Xiaoxiao Wu, Xiaoxiao Wu, Xiaoxiao Wu, Junguo Duan, Junguo Duan, Junguo Duan, Junguo Duan   +18 more
doaj   +1 more source

Interconnection between several eye biomechanical and biometric parameters in children with axial and refractive mild myopia

Zaporožskij Medicinskij Žurnal, 2016
Aim – to study the relationship of biometric and biomechanical indicators of corneoscleral capsule of the eye in children with axial and refractive mild myopia. Materials and methods.
T. Ye. Tsybulskaya
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Evaluation of different techniques of measurement of the axial length in silicone oil-filled eyes

Journal of the Egyptian Ophthalmological Society
Purpose To evaluate different techniques of axial length measurement in silicone oil-filled eyes and compare the results of each with the original axial length measured before pars plana vitrectomy and silicone oil injection for accurate measurement of ...
Ghada A. Nassar, Ehsan El-Mehelmy, Kirollos Joseph, Ahmed A. Mohalhal   +3 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Intraocular pressure and axial length in children

Korean Journal of Ophthalmology, 1990
The intraocular pressure and the anteroposterior length of the eye are of great clinical importance for the diagnosis and management, before and after surgery, of congenital glaucoma. It is well-known that normal intraocular pressure in children is different from the normal levels in adults.
D H, Youn, Y S, Yu, I W, Park
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Association between ocular axial length and anthropometrics of Asian adults

BMC Research Notes, 2021
Objective The purpose of this study is to analyze axial length, body height, hand length, and foot length to find new factors that predict myopia and to identify gender differences as one of the factors of high myopia.
Ari Shinojima, Toshihide Kurihara, Kiwako Mori, Yujiro Iwai, Akiko Hanyuda, Kazuno Negishi, Hidemasa Torii, Kazuo Tsubota   +7 more
doaj   +1 more source