Results 41 to 50 of about 236,478 (267)

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi   +5 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Axial Compressive Performance of Steel-Reinforced Concrete Columns with Monosymmetric Cross-Shaped Steel

open access: yesAdvances in Civil Engineering, 2021
The axial compressive performance of steel-reinforced concrete columns with monosymmetric cross-shaped steel (SRCC-MCS) was investigated in this study.
Jipeng Yu   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Axial Ratio of the Projected Polarization Ellipse [PDF]

open access: yesAustralian Journal of Physics, 1964
The axial ratio of the polarization ellipse of a radio wave is often evalp,ated using a crossed-dipole antenna system placed in a horizontal plane. The axial ratio of the ellipse as deduced from the responses of the two antennas should correspond to the axial ratio of the ellipse in the wave-front as projected onto the horizontal plane. When one of the
openaire   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Axial Length–Disc Area Ratio in Esotropic Amblyopia [PDF]

open access: yesArchives of Ophthalmology, 2003
Hyperopia is a risk factor for esotropia and amblyopia. A previous study indicated that disc areas (DAs) are reduced in patients with amblyopia.To determine if there is a difference in the relative size of the optic disc in hyperopic eyes without strabismus or amblyopia compared with esotropic and amblyopic eyes, the relationship of axial length (AXL ...
openaire   +2 more sources

Reconfigurable Axial Ratio in Compact GNSS Antennas [PDF]

open access: yesIEEE Transactions on Antennas and Propagation, 2016
A new adaptive technique for steering the direction of minimum axial ratio (AR) (<1 dB) toward the reflected or jamming signal is proposed for global navigation satellite systems antennas. It relies on simple, low cost commercially available circularly polarized antenna elements without influencing their gain.
A. Narbudowicz   +2 more
openaire   +3 more sources

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