Results 61 to 70 of about 236,478 (267)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Structural behavior of tree-like steel columns subjected to combined axial and lateral loads

open access: yesJournal of the Mechanical Behavior of Materials, 2022
Few studies have been conducted on the structural behavior of steel columns with branches that are called tree-like columns. These kinds of columns have been used in many structures around the world.
Dekhn Rabab C., Shadhan Khalid K.
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Effect of the axial compression ratio on the seismic behavior of resilient concrete walls with concealed column stirrups

open access: yesReviews on Advanced Materials Science, 2023
The axial compression ratio is one of the important factors affecting the seismic performance of reinforced concrete (RC) walls. Thus, the axial compression ratio is critical in the seismic design of RC walls.
Yuan Weiguang   +3 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Multistage axial hydro-forging sequence of double-stepped tube with large expansion ratio

open access: yesInternational Journal of Lightweight Materials and Manufacture, 2020
In order to manufacture the double-stepped tube with large expansion ratio, a multistage axial hydro-forging sequence was proposed by combination of hydroforming with movable dies in this paper. The new forming process is divided into four stages. In the
Lei Sun   +3 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Bearing capacity of welded composite T-shaped concrete-filled steel tubular columns under axial compression

open access: yesAdvances in Mechanical Engineering, 2020
The axial compressive experiments were carried out on 21 welded composite T-shaped concrete-filled steel tubular columns, and 395 finite element models were established for parameter calculation.
Bing Cao   +6 more
doaj   +1 more source

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