Results 71 to 80 of about 236,478 (267)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A Circularly Polarized Broadband Composite Spiral Antenna for Ground Penetrating Radar

Sensors
To enhance the capability of a ground penetrating radar (GPR) in subsurface target identification and improve its polarization sensitivity in detecting underground linear objects, a circularly polarized broadband composite spiral antenna was designed ...
Hai Liu, Shangyang Zhang, Pei Wu, Xu Meng, Junyong Zhou, Yanliang Du   +5 more
doaj   +1 more source

VISCOSITY AND AXIAL RATIO OF SHELLAC

, 1947
Molecular axial ratios for hard resin, soft ruin and dewaxed shellac have been calculated from viscometric data using different solvents (EtOH. PrOH and BuOH). The ratio 10.3 for dewaxed shellac has been found to be a weighted average of the values for hard resin (11.3) and soft resin (7.8).
openaire   +2 more sources

Ellipsoidal mass models with varying axial ratios [PDF]

Astronomy & Astrophysics, 2004
A family of triaxial mass models is described, for which the density is stratified on coaxial ellipsoids with varying axial ratios. The contours of constant projected density are almost perfect ellipses with ellpticity variations and isophote twists, but with no significant high-order residuals. These models are generalization of the triaxial models of
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Dynamic Mechanical Properties and Failure Mode of Artificial Frozen Silty Clay Subject to One-Dimensional Coupled Static and Dynamic Loads

Advances in Civil Engineering, 2019
The dynamic stress-strain relationship of artificial frozen silty clay under one-dimensional coupled static and dynamic loads is obtained using modified split Hopkinson pressure bar (SHPB) equipment. The variation in dynamic compressive strength, dynamic
Dong-dong Ma, Qin-yong Ma, Zhao-ming Yao, Pu Yuan, Rong-rong Zhang   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A Rotation-Controlled Anisotropic Hourglass Metasurface for Multiband Reflective Linear-to-Circular and Cross- Polarization Conversion

IEEE Access
This paper presents and experimentally validates a multifunctional anisotropic metasurface (MS) that exhibits linear-to-linear (LTL) reflective cross-polarization (RCP) and circular polarization conversion (CPC) responses across multiple frequency ranges.
Muhammad Nasir, Slawomir Koziel, Anna Pietrenko-Dabrowska   +2 more
doaj   +1 more source

An Empirical Study of Overlapping Rotor Interference for a Small Unmanned Aircraft Propulsion System

Aerospace, 2016
The majority of research into full-sized helicopter overlapping propulsion systems involves co-axial setups (fully overlapped). Partially overlapping rotor setups (tandem, multirotor) have received less attention, and empirical data produced over the ...
Mantas Brazinskas, Stephen D. Prior, James P. Scanlan   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source