Results 51 to 60 of about 236,478 (267)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Broadband Circularly Polarized Printed Crossed-Dipole Antenna and Its Arrays for Cellular Base Stations

IEEE Access
This study presents and investigates broadband circularly polarized (CP) printed crossed dipole antenna and its arrays. The proposed antenna comprises a pair of crossed fan-shaped dipoles, two kinds of parasitic elements, and a reflector with two ...
Mehdi Sefidi, Changiz Ghobadi, Javad Nourinia, Rahim Naderali   +3 more
doaj   +1 more source

A Travelling-Wave-Fed Slot Spiral Antenna With Wide Axial-Ratio Bandwidth and Beamwidth for GNSS Applications

IEEE Open Journal of Antennas and Propagation, 2021
A travelling-wave-fed slot spiral antenna with wide axial-ratio (AR) bandwidth and beamwidth for GNSS applications is proposed in this paper. The evolution procedure of the proposed antenna can be classified into three steps. Firstly, 12 identical spiral
Zeng-Pei Zhong, Xiao Zhang
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual‐loop antennas with an expanded axial ratio bandwidth

Electronics Letters, 2023
The authors propose a novel dual‐wire antenna with a balanced feed to increase a 3‐dB axial ratio bandwidth. The antenna comprises loop elements with quasi two‐sources, and the effects of the element distance on the axial ratio bandwidth are revealed ...
Kazuhide Hirose, Koki Nishino, Hisamatsu Nakano   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Multifunctional Metasurface for Linear-to-Linear and Linear-to-Circular Polarization Conversion

IEEE Access
This paper presents a compact, multifunctional, passive polarization-converting metasurface (PCM) designed for linear-to-linear polarization (LTLP) and linear-to-circular polarization (LTCP) conversion across distinct, non-overlapping frequency bands ...
Mujahid Ali Shah, Mirza Shujaat Ali, Ahmed Naeem, Sadiq Ullah, Muhammad Imran, Qammer Abbasi, Huseyin Arslan   +6 more
doaj   +1 more source

Evidence for Room-Temperature Multiferroicity in a Compound with a Giant Axial Ratio

Physical Review Letters, 2009
In the search for multiferroic materials magnetic compounds with a strongly elongated unit-cell (large axial ratio c/a) have been scrutinized intensely. However, none was hitherto proven to have a switchable polarization, an essential feature of ferroelectrics.
Béa, H., Dupé, B., Fusil, S., Mattana, R., Jacquet, E., Warot-Fonrose, Bénédicte, Wilhelm, F., Rogalev, A., Petit, S., Cros, V., Anane, A., Petroff, F., Bouzehouane, K., Geneste, G., Dkhil, B., Lisenkov, S., Ponomareva, I., Bellaiche, L., Bibes, M., Barthélémy, A.   +19 more
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source