Results 41 to 50 of about 429,043 (216)

Integrated Single‐Cell and Spatial Transcriptomics Reveal Convergence on a Senescence‐Associated B Cell–MIF Signaling Axis in Joint Aging and Osteoarthritis Progression

Advanced Science, EarlyView.
Single‐cell and spatial transcriptomics implicate senescent B cells and macrophage migration inhibitory factor (MIF) signaling in aging and osteoarthritic joints. An injectable hydrogel combining quercetin with siRNA targeting MIF attenuates cartilage degeneration in a mouse model of osteoarthritis.
Weida Li, Yi Wang, Yongqing You, Yue Cui, Jiayun Liu, Xingbiao Ma, QiuYu Zhu, Qiang Wu, Zanjing Zhai, Zuyan Lu, Kerong Dai, Ye Sun   +11 more
wiley   +1 more source

Biomarkers for successful tapering of a tumor necrosis factor inhibitor in patients with radiographic axial spondyloarthritis: A pilot study

SAGE Open Medicine
Background: Tumor necrosis factor inhibitors are the most widely used biological disease-modifying antirheumatic drugs for radiographic axial spondyloarthritis.
Hong Ki Min, Ji-Yeon Lee
doaj   +1 more source

Descending Aorta Calcinosis and Hypertension in Patients with Radiographic Axial Spondyloarthritis

Український журнал серцево-судинної хірургії
This article is the result of our own clinical observations and a literature search on the development of aortic calcification and hypertension syndrome in patients with axial spondyloarthritis, as well as the clinical significance of the combination of
О. Г. Аксьонова, Г. Д. Кіржнер, Я. І. Смаровоз   +2 more
doaj   +1 more source

Novel Therapeutic Targets in Axial Spondyloarthritis [PDF]

, 2018
Purpose of review Axial spondyloarthritis remains an area of significant unmet clinical need with only two immune pathways currently targeted by licenced therapies compared to other immune-mediated inflammatory joint disorders such as rheumatoid ...
M. Hussein Al-Mossawi, Claudia Worth, Paul Bowness   +2 more
core   +1 more source

Australian Consensus Statements for the Assessment and Management of Non-radiographic Axial Spondyloarthritis

, 2021
Background: The understanding of non-radiographic axial spondyloarthritis (nr-axSpA) has accelerated over the last decade, producing a number of practice-changing developments. Diagnosis is challenging.
Schachna, L, Saad, NF, Robinson, PC, Taylor, AL, Truong, SL, McEwan, T, Bird, P, Lim, I, Steven L. Truong, Paul Bird, Lionel Schachna, Nivene F. Saad, Tim McEwan, Irwin Lim, Andrew L. Taylor, Philip C. Robinson   +15 more
core   +1 more source

Axial Spondyloarthritis and Cigarette Smoking [PDF]

The Open Rheumatology Journal, 2017
Background:Smoking is one of the main environmental risk factors involved in several rheumatic diseases according to ACR 2014, it is included among the risk factors for severe axial spondyloarthritis.Objectives:The objective is to study the association between smoking and the activity of the disease, the functional impact and the severity of the axial ...
Kaut, Irène Kona, abourazzak, Fatima Ezzhara, Jamila, Essouri, Sènami, Florine Awassi, Diketa, Desiré, Taoufik, Harzy   +5 more
openaire   +2 more sources

High‐Resolution Deep Learning Dixon Magnetic Resonance Imaging of the Sacroiliac Joints Is Noninferior to Standard Magnetic Resonance Imaging in Patients With Suspected Axial Spondyloarthritis

Arthritis &Rheumatology, EarlyView.
Objective To compare the multisequence standard magnetic resonance imaging (sMRI) protocol of the sacroiliac joints with a single high‐resolution deep learning–reconstructed Dixon sequence (DL‐Dixon) in patients with suspected axial spondyloarthritis (axSpA). Methods Seventy‐six patients with chronic low back pain and suspected axSpA underwent clinical,
Dominik Deppe, Mariam Koka, Fabian Proft, Sevtap Tugce Ulas, Kay‐Geert Hermann, Denis Poddubnyy, Mikhail Protopopov, Henriette Baum, Hildrun Haibel, Mehrgan Shahryari, Valeria Rios Rodriguez, Jens Vogel‐Claussen, Torsten Diekhoff   +12 more
wiley   +1 more source

Comparison of Clinical Features in Hla-B27 Positive and Negative Patients with Axial Spondyloarthritis

Pakistan Armed Forces Medical Journal
Objective: To compare the clinical features of HLA-B27 positive and negative patients having axial spondyloarthritis. Study Design: Qusai-experimental study.
Hassan Shaukat, Amer Fakhr, Zohra Tasleem, Ghulam Abbas Niazi, Amina Khurshid, Farzana Hakim   +5 more
doaj   +1 more source

Epidemiology of axial spondyloarthritis: an update [PDF]

Current Opinion in Rheumatology, 2018
Purpose of review To provide an update of the prevalence and incidence of axial spondyloarthritis in the general population and in patients with spondyloarthritis-related conditions, environmental risk factors for ankylosing spondylitis, progression from nonradiographic axial spondyloarthritis to ankylosing spondylitis ...
Runsheng, Wang, Michael M, Ward
openaire   +2 more sources

Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi, Seyoung Jung, Jeong Ho Joo, Young‐Eun Kim, Heounjeong Go, Yong‐Gil Kim, Chang‐Keun Lee, Bin Yoo, Jeong Seok Lee, Seokchan Hong   +9 more
wiley   +1 more source