Results 141 to 150 of about 2,423,656 (318)

Control based power smoothing for aggregated vertical axis wind turbines

open access: yes, 2012
Recently there has been renewed interest in the potential of vertical axis wind turbines (VAWTs), particularly, at very large scale of 10 MW or above owing to their structural simplicity.
Leithead, William   +2 more
core  

LSMAT Least Squares Medial Axis Transform

open access: yes, 2019
The medial axis transform has applications in numerous fields including visualization, computer graphics, and computer vision. Unfortunately, traditional medial axis transformations are usually brittle in the presence of outliers, perturbations and/or ...
Rebain, Daniel   +6 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Computational flow field analysis of a Vertical Axis Wind Turbine

open access: yes
The present work has used Computational Fluid Dynamics (CFD) to obtain the flow field characteristics of a novel Vertical Axis Wind Turbine (VAWT). The turbine used in this study features a multi blade design where both a stator and rotor blade array is ...
Colley, Gareth, Mishra, Rakesh
core  

A method for analysing fluid structure interactions on a horizontal axis tidal turbine

open access: yes, 2011
Free stream tidal turbines are rotating bodies in fast flowing tidal currents, and as such are exposed to fluctuating loads from the surrounding fluid.
Nicholls-Lee, R.F.   +2 more
core  

SUGERENCIAS DESDE UN CONTEXTO FUNERARIO EN UN "ESPACIO VACÍO" DEL DESIERTO DE ATACAMA SUGGESTIONS FROM A FUNERARY CONTEXT IN AN "EMPTY SPACE" OF THE ATACAMA DESERT

open access: yesBoletín del Museo Chileno de Arte Precolombino, 2008
Este trabajo presenta el estudio de caso de un contexto funerario situado en la pampa adyacente a la actual oficina salitrera de María Elena, norte de Chile.
BÁRBARA CASES   +4 more
doaj  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

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