Results 111 to 120 of about 479,230 (336)

Slovak database of speech affected by neurodegenerative diseases

Scientific Data
A new Slovak speech database EWA-DB was created for research purposes aimed at early detection of neurodegenerative diseases from speech. It contains 1649 speakers performing various speech and language tasks, such as sustained vowel phonation ...
Milan Rusko, Róbert Sabo, Marián Trnka, Alfréd Zimmermann, Richard Malaschitz, Eugen Ružický, Petra Brandoburová, Viktória Kevická, Matej Škorvánek   +8 more
doaj   +1 more source

Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves

Frontiers in Cellular Neuroscience, 2017
The pannexin family of channels consists of three members—pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments.
Steven M. Horton, Carlos Luna Lopez, Elisabeth Blevins, Elisabeth Blevins, Holly Howarth, Jake Weisberg, Valery I. Shestopalov, Helen P. Makarenkova, Sameer B. Shah, Sameer B. Shah, Sameer B. Shah   +10 more
doaj   +1 more source

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

Advanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen, Yvonne Shen, Yutong Shao, Tenghuan Ge, Haowen Qiao, Shangzhou Xia, Yafei Qu, Yuanpu Chiu, Ying Qin, Zhen Zhao   +9 more
wiley   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Differential signaling via the same axon of neocortical pyramidal neurons.

Proceedings of the National Academy of Sciences of the United States of America, 1998
The nature of information stemming from a single neuron and conveyed simultaneously to several hundred target neurons is not known. Triple and quadruple neuron recordings revealed that each synaptic connection established by neocortical pyramidal neurons
H. Markram, Yun Wang, M. Tsodyks
semanticscholar   +1 more source

Limited Physical Functioning in United States Adults with Arthritis: Findings from the 2021 Medical Expenditure Panel Survey

Diseases
There is little published research on limited physical functioning in United States (US) adults with arthritis. The objective of this cross-sectional 2021 Medical Expenditure Panel Survey (MEPS) database study was to investigate the variables associated ...
David R. Axon
doaj   +1 more source

Phage display: development of nanocarriers for targeted drug delivery to the brain

Neural Regeneration Research, 2015
The blood brain barrier represents a formidable obstacle for the transport of most systematically administered neurodiagnostics and neurotherapeutics to the brain.
Babak Bakhshinejad, Marzieh Karimi, Mohammad Khalaj-Kondori   +2 more
doaj   +1 more source

3D‐Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
3D‐printed organoid scaffolds with microscale channels are developed to enhance spinal cord injury recovery by guiding region‐specific spinal neural progenitor cells. These scaffolds promote axonal growth, cell maturation, and neuronal network formation.
Guebum Han, Nicolas S. Lavoie, Nandadevi Patil, Olivia G. Korenfeld, Hyunjun Kim, Manuel Esguerra, Daeha Joung, Michael C. McAlpine, Ann M. Parr   +8 more
wiley   +1 more source

Low-frequency transcranial magnetic stimulation is beneficial for enhancing synaptic plasticity in the aging brain

Neural Regeneration Research, 2015
In the aging brain, cognitive function gradually declines and causes a progressive reduction in the structural and functional plasticity of the hippocampus. Transcranial magnetic stimulation is an emerging and novel neurological and psychiatric tool used
Zhan-chi Zhang, Feng Luan, Chun-yan Xie, Dan-dan Geng, Yan-yong Wang, Jun Ma   +5 more
doaj   +1 more source

Covalent Binding of Dexamethasone to Polyimide Improves Biocompatibility of Neural Implantable Devices

Advanced Healthcare Materials, EarlyView.
The covalent binding of dexamethasone to the surface of polyimide represents the electrically inert part of implantable intraneural devices. This ensures a sustained release of the drug for 9 weeks. In vitro and in vivo tests confirm the reduction of the foreign body reactions and the improved biocompatibility of dexamethasone functionalized polyimide.
Giulia Turrin, Jose Crugeiras, Chiara Bisquoli, Davide Barboni, Martina Catani, Bruno Rodríguez‐Meana, Rita Boaretto, Michele Albicini, Stefano Caramori, Claudio Trapella, Thomas Stieglitz, Yara Baslan, Hanna Karlsson‐Fernberg, Fernanda L. Narvaez‐Chicaiza, Edoardo Marchini, Alberto Cavazzini, Ruben López‐Vales, Maria Asplund, Xavier Navarro, Stefano Carli   +19 more
wiley   +1 more source