Results 11 to 20 of about 434,135 (356)
Physiological Reviews, 2011 Axons are generally considered as reliable transmission cables in which stable propagation occurs once an action potential is generated. Axon dysfunction occupies a central position in many inherited and acquired neurological disorders that affect both peripheral and central neurons.
Debanne, Dominique +4 more
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Axonal transport during injury on a theoretical axon
Frontiers in Cellular Neuroscience, 2023 Neurodevelopment, plasticity, and cognition are integral with functional directional transport in neuronal axons that occurs along a unique network of discontinuous polar microtubule (MT) bundles. Axonopathies are caused by brain trauma and genetic diseases that perturb or disrupt the axon MT infrastructure and, with it, the dynamic interplay of motor ...
Soumyadeep Chandra +6 more
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Alzheimer’s Research & Therapy, 2018 Background Neurofibrillary pathology composed of tau protein is closely correlated with severity and phenotype of cognitive impairment in patients with Alzheimer’s disease and non-Alzheimer’s tauopathies.
Petr Novak +19 more
doaj +1 more source
Development and Implementation of a Healthcare Database Analysis Course for Graduate Students
Pharmacy, 2022 There emerged a need to develop and implement a new healthcare database analysis course for Health Economics and Outcomes Research (HEOR) graduate students, which would allow students to apply their biostatistics and study design skills to answer ...
David R. Axon
doaj +1 more source
Genomic Analysis of Drosophila Neuronal Remodeling: A Role for the RNA-Binding Protein Boule as a Negative Regulator of Axon Pruning [PDF]
, 2008 Drosophila mushroom body (MB) {gamma} neurons undergo axon pruning during metamorphosis through a process of localized degeneration of specific axon branches.
Hoopfer, Eric D. +3 more
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Pharmacy, 2023 This study aimed to assess third-year student pharmacists’ perspectives regarding a virtually delivered research proposal course. A 23-item questionnaire was distributed to third-year student pharmacists enrolled in a research proposal course over three ...
David R. Axon
doaj +1 more source
Axon degeneration: Linking axonal bioenergetics to myelin [PDF]
Journal of Cell Biology, 2016 The mechanisms by which axonal degeneration occurs, even in the presence of apparently normal myelin sheaths, remain unknown. In this issue, Yin et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607099) study mutant mice in which proteolipid protein is replaced by the peripheral myelin protein P0 and describe a number of early axonal ...
Beirowski, Bogdan +2 more
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The Tumor Suppressor HHEX Inhibits Axon Growth when Prematurely Expressed in Developing Central Nervous System Neurons [PDF]
, 2015 Neurons in the embryonic and peripheral nervoussystem respond to injury by activating transcriptional programs supportive of axon growth, ultimately resulting in functional recovery.
Blackmore, Murray G. +9 more
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Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead
Frontiers in Neuroscience, 2018 Neurofibrillary pathology comprised of pathological tau protein is closely tied to a range of neurodegenerative disorders, the most common of which is Alzheimer’s disease.
Petr Novak +7 more
doaj +1 more source