Results 271 to 280 of about 304,829 (369)

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

Neuron identity switches in response to the gradient gene expression pathway. [PDF]

Front Cell Neurosci
Guzmán G, Paredes O, Romo-Vázquez R, Vélez-Pérez H, Morales JA.   +4 more
europepmc   +1 more source

Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
This study identifies a class of amino acid‐sensing neurons, APCCRH neurons, which regulate BAT thermogenesis. Leucine deficiency alters intrinsic excitability through GCN2 signaling pathway, activating APCCRH neurons, which in turn regulate BAT thermogenesis via projections to the lateral hypothalamus.
Peixiang Luo, Kexin Tong, Yeting Gan, Min Tang, Yuguo Niu, Kan Liu, Shihong Ni, Shangming Wu, Xiaoxue Jiang, Haizhou Jiang, Fei Xiao, Shanghai Chen, Wei Lv, Xiaoying Li, Feixiang Yuan, Feifan Guo   +15 more
wiley   +1 more source

The effect of diluting the internal solution on the electrical properties of a perfused giant axon

, 1964
P. F. Baker, A. L. Hodgkin, H. Meves
openalex   +2 more sources

Microenvironmental Modulation for Therapeutic Efficacy of Extracellular Vesicles

Advanced Science, EarlyView.
Recent studies highlighted the heterogeneity of EVs and the influence of microenvironmental signals on their therapeutic efficacy. This review offers a comprehensive overview of strategies and mechanisms to optimize the therapeutic efficacy of EVs through physical, biochemical, and mechanical modulation.
Bilu Xiang, Shiying Zhang, Irene Shuping Zhao, Xueqi Gan, Yang Zhang   +4 more
wiley   +1 more source

<b>Structure of myelin in the central nervous system and another possible driving force for its formation</b>-<b>myelin compaction</b>. [PDF]

J Zhejiang Univ Sci B
Shao Q, Chen S, Xu T, Shi Y, Sun Z, Wang Q, Wang X, Cheng F.   +7 more
europepmc   +1 more source

Partial inhibition of the active transport of cations in the giant axons of Loligo

, 1960
P. C. Caldwell, A. L. Hodgkin, R. D. Keynes, T. I. Shaw   +3 more
openalex   +2 more sources

The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression

Advanced Science, EarlyView.
LC‐GABA neurons exhibit elevated activity to noxious and aversive stimuli in chronic pain, and their activation alleviates pain‐ and depression‐like behaviors. While LC‐GABA neurons target LC‐NA neurons and GABA and Glu neurons in the vlPAG, they modulate the pain responses of LC‐NA neurons but regulate pain‐ and depression‐like behaviors through their
Yuan Gao, Xue Zhang, Xiao‐Juan Liu, Yi‐Ling Sun, Cui Yin, Dong‐Liang Tang, Cheng Xiao, Chunyi Zhou   +7 more
wiley   +1 more source

Effects of Redox and Sulfhydryl Reagents on the Bioelectric Properties of the Giant Axon of the Squid

, 1966
F. Huneeus-Cox, Hugo L. Fernández, Blair H. Smith   +2 more
openalex   +1 more source

Neuron‐Inspired Biomolecular Memcapacitors Formed Using Droplet Interface Bilayer Networks

Advanced Electronic Materials, EarlyView.
In this article, a biomolecular model neuron capable of integrating charge is proposed, evaluated, and simulated as a soft neuromorphic device. The device traps charge within microfluidic droplets using lipid membranes and voltage‐activated pores. The trapped charge produces electrowetting of the lipid interfaces, which facilitates multiple memory ...
Braydon Segars, Kyle Rosenberg, Sarita Shrestha, Joshua J. Maraj, Stephen A. Sarles, Eric Freeman   +5 more
wiley   +1 more source