Results 1 to 10 of about 902,976 (291)

Exosomes: new targets for understanding axon guidance in the developing central nervous system [PDF]

Frontiers in Cell and Developmental Biology
Axon guidance is a key event in neural circuit development that drives the correct targeting of axons to their targets through long distances and unique patterns.
Teng Teng
exaly   +4 more sources

Axon Guidance Molecules and Pain [PDF]

Cells, 2022
Chronic pain is a debilitating condition that influences the social, economic, and psychological aspects of patients’ lives. Hence, the need for better treatment is drawing extensive interest from the research community.
Elisa Damo, Manuela Simonetti
doaj   +4 more sources

microRNAs in axon guidance [PDF]

Frontiers in Cellular Neuroscience, 2014
Brain wiring is a highly intricate process in which trillions of neuronal connections are established. Its initial phase is particularly crucial in establishing the general framework of neuronal circuits.
Archana N Iyer, Anais eBellon, Marie-Laure Michele Baudet   +2 more
doaj   +3 more sources

Cbln1 regulates axon growth and guidance in multiple neural regions

PLoS Biology, 2022
The accurate construction of neural circuits requires the precise control of axon growth and guidance, which is regulated by multiple growth and guidance cues during early nervous system development.
Sheng-Jian Ji, Samie R. Jaffrey, Zhuoxuan Yang   +2 more
exaly   +2 more sources

The role of axon guidance molecules in the pathogenesis of epilepsy [PDF]

Neural Regeneration Research
Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms
Zheng Liu, Chunhua Pan, Hao Huang
doaj   +2 more sources

miR-92 Suppresses Robo1 Translation to Modulate Slit Sensitivity in Commissural Axon Guidance

Cell Reports, 2018
Summary: Temporospatial regulation of guidance signaling is essential for axon outgrowth and pathfinding in the developing nervous system. Regulation of Robo1 levels in commissural neurons modulates Slit sensitivity facilitating proper axon guidance. The
Qiangqiang Shao, Tao Yang, Guofa Liu
exaly   +3 more sources

Roundabout receptor signaling: beyond axon guidance [PDF]

Signal Transduction and Targeted Therapy
Naresh L. Selokar, Wilfried A. Kues
doaj   +2 more sources

Multiple Functions of Draxin/Netrin-1 Signaling in the Development of Neural Circuits in the Spinal Cord and the Brain

Frontiers in Neuroanatomy, 2021
Axon guidance proteins play key roles in the formation of neural circuits during development. We previously identified an axon guidance cue, named draxin, that has no homology with other axon guidance proteins.
Giasuddin Ahmed, Yohei Shinmyo
doaj   +1 more source

Endoglycan plays a role in axon guidance by modulating cell adhesion

eLife, 2021
Axon navigation depends on the interactions between guidance molecules along the trajectory and specific receptors on the growth cone. However, our in vitro and in vivo studies on the role of Endoglycan demonstrate that in addition to specific guidance ...
Thomas Baeriswyl, Alexandre Dumoulin, Martina Schaettin, Georgia Tsapara, Vera Niederkofler, Denise Helbling, Evelyn Avilés, Jeannine A Frei, Nicole H Wilson, Matthias Gesemann, Beat Kunz, Esther T Stoeckli   +11 more
doaj   +1 more source

Transcriptional control in embryonic Drosophila midline guidance assessed through a whole genome approach

BMC Neuroscience, 2007
Background During the development of the Drosophila central nervous system the process of midline crossing is orchestrated by a number of guidance receptors and ligands.
Tomancak Pavel, Palmer Jessica, Magalhães Tiago R, Pollard Katherine S   +3 more
doaj   +1 more source