Results 1 to 10 of about 1,064,643 (248)
Expression of Genes Involved in Axon Guidance: How Much Have We Learned?
International Journal of Molecular Sciences, 2020 Neuronal axons are guided to their target during the development of the brain. Axon guidance allows the formation of intricate neural circuits that control the function of the brain, and thus the behavior.
Sung Wook Kim +2 more
exaly +2 more sources
The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance
Cell Reports, 2019 Summary: The small GTPase Arl13b is enriched in primary cilia and regulates Sonic hedgehog (Shh) signaling. During neural development, Shh controls patterning and proliferation through a canonical, transcription-dependent pathway that requires the ...
Julien Ferent +8 more
doaj +2 more sources
Cbln1 regulates axon growth and guidance in multiple neural regions
PLoS Biology, 2022 The accurate construction of neural circuits requires the precise control of axon growth and guidance, which is regulated by multiple growth and guidance cues during early nervous system development.
Zhuoxuan Yang +2 more
exaly +2 more sources
Floor-plate-derived netrin-1 is dispensable for commissural axon guidance
Nature, 2017 Netrin-1 is an evolutionarily conserved, secreted extracellular matrix protein involved in axon guidance at the central nervous system midline. Netrin-1 is expressed by cells localized at the central nervous system midline, such as those of the floor ...
Juan Antonio Moreno-Bravo +2 more
exaly +2 more sources
NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance
Nature Communications, 2020 Robo3 is a divergent, multifunctional member of the Robo receptor family that mediates axon guidance by its ligand NELL2 instead of the canonical Slit ligands.
Joseph S. Pak +6 more
doaj +2 more sources
Dystroglycan is a scaffold for extracellular axon guidance decisions
eLife, 2019 Axon guidance requires interactions between extracellular signaling molecules and transmembrane receptors, but how appropriate context-dependent decisions are coordinated outside the cell remains unclear.
L Bailey Lindenmaier +4 more
doaj +2 more sources
Commissural axon guidance in the developing spinal cord: from Cajal to the present day
Neural Development, 2019 During neuronal development, the formation of neural circuits requires developing axons to traverse a diverse cellular and molecular environment to establish synaptic contacts with the appropriate postsynaptic partners.
J. D. Comer +3 more
doaj +2 more sources
Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons
Cell Reports, 2015 Axon guidance relies on precise translation of extracellular signal gradients into local changes in cytoskeletal dynamics, but the molecular mechanisms regulating dose-dependent responses of growth cones are still poorly understood.
Martin Balastik +15 more
doaj +2 more sources
miR-92 Suppresses Robo1 Translation to Modulate Slit Sensitivity in Commissural Axon Guidance
Cell Reports, 2018 Summary: Temporospatial regulation of guidance signaling is essential for axon outgrowth and pathfinding in the developing nervous system. Regulation of Robo1 levels in commissural neurons modulates Slit sensitivity facilitating proper axon guidance. The
Tao Yang +2 more
exaly +3 more sources