Results 41 to 50 of about 1,064,643 (248)
Cannabinoid receptor CB2 modulates axon guidance. [PDF]
PLoS ONE, 2013 Navigation of retinal projections towards their targets is regulated by guidance molecules and growth cone transduction mechanisms. Here, we present in vitro and in vivo evidences that the cannabinoid receptor 2 (CB2R) is expressed along the retino ...
Gabriel Duff +8 more
doaj +1 more source
Cell migration and axon guidance at the border between central and peripheral nervous system
Science, 2019 Neurons negotiating boundaries Barriers around the brain and spinal cord separate central from peripheral nervous systems, yet the two systems are interlinked.
T. Suter, Alexander Jaworski
semanticscholar +1 more source
Axon guidance pathways and the control of gene expression
Developmental Dynamics, 2018 Axons need to be properly guided to their targets to form synaptic connections, and this requires interactions between highly conserved extracellular and transmembrane ligands and their cell surface receptors.
Samantha A Russell, Greg J. Bashaw
semanticscholar +1 more source
Guidance Molecules in Axon Regeneration [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 The regenerative capacity of injured adult mammalian central nervous system (CNS) tissue is very limited. Disease or injury that causes destruction or damage to neuronal networks typically results in permanent neurological deficits. Injury to the spinal cord, for example, interrupts vital ascending and descending fiber tracts of spinally projecting ...
Roman J, Giger +2 more
openaire +2 more sources
Decreased expression of axon-guidance receptors in the anterior cingulate cortex in autism
Molecular Autism, 2011 Background Axon-guidance proteins play a crucial role in brain development. As the dysfunction of axon-guidance signaling is thought to underlie the microstructural abnormalities of the brain in people with autism, we examined the postmortem brains of ...
Suda Shiro +15 more
doaj +1 more source
Mathematical guidance for axons
Trends in Neurosciences, 1998 Axon guidance by gradients plays an important role in wiring up the developing nervous system. Growth cones seem to sense a concentration difference across their spatial extent, and convert this into a signal to move up or down a gradient. In this article, a simple mathematical framework is developed to understand when and where gradient detection can ...
openaire +5 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The Caenorhabditis elegans Eph receptor activates NCK and N-WASP, and inhibits Ena/VASP to regulate growth cone dynamics during axon guidance. [PDF]
PLoS Genetics, 2012 The Eph receptor tyrosine kinases (RTKs) are regulators of cell migration and axon guidance. However, our understanding of the molecular mechanisms by which Eph RTKs regulate these processes is still incomplete.
Ahmed M Mohamed +4 more
doaj +1 more source
A mathematical model explains saturating axon guidance responses to molecular gradients
eLife, 2016 Correct wiring is crucial for the proper functioning of the nervous system. Molecular gradients provide critical signals to guide growth cones, which are the motile tips of developing axons, to their targets.
Huyen Nguyen +4 more
semanticscholar +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source