Results 21 to 30 of about 1,064,643 (248)
BMC Neuroscience, 2007 Background During the development of the Drosophila central nervous system the process of midline crossing is orchestrated by a number of guidance receptors and ligands.
Tomancak Pavel +3 more
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The midline protein regulates axon guidance by blocking the reiteration of neuroblast rows within the Drosophila ventral nerve cord. [PDF]
PLoS Genetics, 2013 Guiding axon growth cones towards their targets is a fundamental process that occurs in a developing nervous system. Several major signaling systems are involved in axon-guidance, and disruption of these systems causes axon-guidance defects. However, the
Mary Ann Manavalan +2 more
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PLoS ONE, 2013 Heparan sulfate proteoglycans (HSPGs) are proteins with long covalently attached sugar side chains of the heparan sulfate (HS) type. Depending on the cellular context HS chains carry multiple structural modifications such as sulfate residues or ...
Stephan Gysi +4 more
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Long-range optogenetic control of axon guidance overcomes developmental boundaries and defects
Developmental Cell, 2020 Axons connect neurons together, establishing the wiring architecture of neuronal networks. Axonal connectivity is largely built during embryonic development through highly constrained processes of axon guidance, which have been extensively studied ...
James M. Harris +7 more
semanticscholar +1 more source
Gastroenterology, 2019 Background & Aims: Little is known about mechanisms of perineural invasion (PNI) by pancreatic ductal adenocarcinomas (PDAs) or other tumors. Annexin A2 (ANXA2) regulates secretion of SEMA3D, an axon guidance molecule, which binds and activates the ...
Noelle R. Jurcak +11 more
semanticscholar +1 more source
G3: Genes, Genomes, Genetics, 2018 During development, neuronal cells extend an axon toward their target destination in response to a cue to form a properly functioning nervous system.
Jamie K. Alan +4 more
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The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression
Nucleic Acids Research, 2019 N 6-Methyladenosine (m6A) is a dynamic mRNA modification which regulates protein expression in various posttranscriptional levels. Functional studies of m6A in nervous system have focused on its writers and erasers so far, whether and how m6A readers ...
Mengru Zhuang +9 more
semanticscholar +1 more source
Neural Development, 2008 Background How axon guidance signals regulate growth cone behavior and guidance decisions in the complex in vivo environment of the central nervous system is not well understood.
Yost H Joseph +5 more
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The Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidance. [PDF]
PLoS Genetics, 2012 The mechanisms linking guidance receptors to cytoskeletal dynamics in the growth cone during axon extension remain mysterious. The Rho-family GTPases Rac and CDC-42 are key regulators of growth cone lamellipodia and filopodia formation, yet little is ...
Rafael S Demarco +2 more
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Optogenetic axon guidance in embryonic zebrafish
STAR Protocols, 2021 Summary: Axons form the long-range connections of biological neuronal networks, which are built through the developmental process of axon guidance. Here, we describe a protocol to precisely and non-invasively control axonal growth trajectories in live ...
James M. Harris +2 more
doaj +1 more source