Results 21 to 30 of about 50,714 (254)
Optogenetic axon guidance in embryonic zebrafish
STAR Protocols, 2021 Summary: Axons form the long-range connections of biological neuronal networks, which are built through the developmental process of axon guidance. Here, we describe a protocol to precisely and non-invasively control axonal growth trajectories in live ...
James M. Harris +2 more
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Where does axon guidance lead us? [version 1; referees: 2 approved]
F1000Research, 2017 During neural circuit formation, axons need to navigate to their target cells in a complex, constantly changing environment. Although we most likely have identified most axon guidance cues and their receptors, we still cannot explain the molecular ...
Esther Stoeckli
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Structural Perspectives on Axon Guidance
Annual Review of Cell and Developmental Biology, 2016 Axon guidance relies on a combinatorial code of receptor and ligand interactions that direct adhesive/attractive and repulsive cellular responses. Recent structural data have revealed many of the molecular mechanisms that govern these interactions and enabled the design of sophisticated mutant tools to dissect their biological functions.
Seiradake, E., Jones, E., Klein, R.
openaire +4 more sources
The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance
Cell Reports, 2019 Summary: The small GTPase Arl13b is enriched in primary cilia and regulates Sonic hedgehog (Shh) signaling. During neural development, Shh controls patterning and proliferation through a canonical, transcription-dependent pathway that requires the ...
Julien Ferent +8 more
doaj +1 more source
PLoS Genetics, 2015 During development, axons must integrate directional information encoded by multiple guidance cues and their receptors. Axon guidance receptors, such as UNC-40 (DCC) and SAX-3 (Robo), can function individually or combinatorially with other guidance ...
Yan Xu +3 more
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Axon guidance molecules in immunometabolic diseases
Inflammation and Regeneration, 2022 The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions.
Yoshimitsu Nakanishi +2 more
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The Role of Apoptotic Signaling in Axon Guidance
Journal of Developmental Biology, 2018 Navigating growth cones are exposed to multiple signals simultaneously and have to integrate competing cues into a coherent navigational response. Integration of guidance cues is traditionally thought to occur at the level of cytoskeletal dynamics ...
Riley Kellermeyer +3 more
doaj +1 more source
Cannabinoid receptor CB2 modulates axon guidance. [PDF]
PLoS ONE, 2013 Navigation of retinal projections towards their targets is regulated by guidance molecules and growth cone transduction mechanisms. Here, we present in vitro and in vivo evidences that the cannabinoid receptor 2 (CB2R) is expressed along the retino ...
Gabriel Duff +8 more
doaj +1 more source
Dystroglycan is a scaffold for extracellular axon guidance decisions
eLife, 2019 Axon guidance requires interactions between extracellular signaling molecules and transmembrane receptors, but how appropriate context-dependent decisions are coordinated outside the cell remains unclear.
L Bailey Lindenmaier +4 more
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TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation
Cell Reports, 2020 Summary: Neuronal migration, axon fasciculation, and axon guidance need to be closely coordinated for neural circuit assembly. Spinal motor neurons (MNs) face unique challenges during development because their cell bodies reside within the central ...
Tracey A.C.S. Suter +5 more
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