An Emerging Role of PRRT2 in Regulating Growth Cone Morphology. [PDF]
Cells, 2021 Mutations in the PRRT2 gene are the main cause for a group of paroxysmal neurological diseases including paroxysmal kinesigenic dyskinesia, episodic ataxia, benign familial infantile seizures, and hemiplegic migraine. In the mature central nervous system,
Savino E +5 more
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A short isoform of the UNC-6/Netrin receptor UNC-5 is required for growth cone polarity and robust growth cone protrusion in <i>Caenorhabditis elegans</i>. [PDF]
Front Cell Dev Biol, 2023 Introduction: UNC-6/Netrin is a conserved bi-functional guidance cue which regulates dorsal-ventral axon guidance in C. elegans. In the Polarity/Protrusion model of UNC-6/Netrin mediated dorsal growth away from UNC-6/Netrin, The UNC-5 receptor first ...
Mahadik SS, Lundquist EA.
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Neurotherapeutic Potential of Cervus elaphus Sibericus on Axon Regeneration and Growth Cone Reformation after H2O2-Induced Injury in Rat Primary Cortical Neurons. [PDF]
Biology (Basel), 2021 Cervus elaphus sibericus (CES), commonly known as deer antler, has been used as a medicinal herb because of its various pharmacological activities, including its anti-infective, anti-arthritic, anti-allergic, and anti-oxidative properties.
Hong JY +9 more
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Growth cone advance requires EB1 as revealed by genomic replacement with a light-sensitive variant. [PDF]
Elife, 2023 A challenge in analyzing dynamic intracellular cell biological processes is the dearth of methodologies that are sufficiently fast and specific to perturb intracellular protein activities.
Dema A +4 more
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β-catenin-α-catenin and actomyosin signaling differentially regulate growth cone contours and axon undulation and branching of retinal ganglion cells <i>in situ</i>. [PDF]
Front Cell NeurosciIntroductionCadherin adhesive and actomyosin signaling are key cytomechanical cues required for neuronal circuit formation, but whether they function together to sculpt developing neurons is not known. Previously, we demonstrated that a β-catenin mutant (
Lew V +6 more
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Glial Cell-Axonal Growth Cone Interactions in Neurodevelopment and Regeneration. [PDF]
Front Neurosci, 2020 The developing nervous system is a complex yet organized system of neurons, glial support cells, and extracellular matrix that arranges into an elegant, highly structured network.
Rigby MJ, Gomez TM, Puglielli L.
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Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment. [PDF]
Cells, 2020 By binding to actin filaments, non-muscle myosin II (NMII) generates actomyosin networks that hold unique contractile properties. Their dynamic nature is essential for neuronal biology including the establishment of polarity, growth cone formation and ...
Costa AR, Sousa MM.
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LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone-growth cone communication. [PDF]
Proc Natl Acad Sci U S A, 2020 Onishi K +6 more
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Growth Factors as Axon Guidance Molecules: Lessons From in vitro Studies
Frontiers in Neuroscience, 2021 Growth cones at the tips of extending axons navigate through developing organisms by probing extracellular cues, which guide them through intermediate steps and onto final synaptic target sites.
Massimo M. Onesto +4 more
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Coactosin Promotes F-Actin Protrusion in Growth Cones Under Cofilin-Related Signaling Pathway
Frontiers in Cell and Developmental Biology, 2021 During brain development, axon outgrowth and its subsequent pathfinding are reliant on a highly motile growth cone located at the tip of the axon. Actin polymerization that is regulated by actin-depolymerizing factors homology (ADF-H) domain-containing ...
Xubin Hou +5 more
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