Results 21 to 30 of about 97,079 (259)
To Stick or Not to Stick: The Multiple Roles of Cell Adhesion Molecules in Neural Circuit Assembly
Frontiers in Neuroscience, 2022 Precise wiring of neural circuits is essential for brain connectivity and function. During development, axons respond to diverse cues present in the extracellular matrix or at the surface of other cells to navigate to specific targets, where they ...
Trevor Moreland, Fabienne E. Poulain
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Growth Cones: Structural, Molecular and Functional Relevance to Neuronal Migration, Regeneration and Reproductive Function [PDF]
Journal of Medical AcademicsThe specialized cells of the human brain form a complex network responsible for neural processing and transmission via various electrochemical signaling pathways.
Mona Sharma, Anmol Garg, Tanya Gupta
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Mechanisms of growth cone repulsion [PDF]
F1000 Biology Reports, 2010 Research conducted in the last century suggested that chemoattractants guide cells or their processes to appropriate locations during development. Today, we know that many of the molecules involved in cellular guidance can act as chemorepellents that prevent migration into inappropriate territories. Here, we review some of the early seminal experiments
Krull, Catherine E, Eisen, Judith S
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Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons
eLife, 2015 During nervous system development, commissural axons cross the midline despite the presence of repellant ligands. In Drosophila, commissural axons avoid premature responsiveness to the midline repellant Slit by expressing the endosomal sorting receptor ...
Timothy A Evans +3 more
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Transcriptional Control of Axon Guidance at Midline Structures
Frontiers in Cell and Developmental Biology, 2022 The development of the nervous system is a time-ordered and multi-stepped process that includes neurogenesis and neuronal specification, axonal navigation, and circuits assembly.
Eloísa Herrera, Augusto Escalante
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Frontiers in Physiology, 2019 Cytoplasmic Actin Gamma 1 (ACTG1) gene variant are autosomal dominant and can cause CNS anomalies (Baraitser Winter Malformation Syndrome; BWMS). ACTG1 anomalies in offspring include agenesis of the corpus callosum (ACC) and neuronal heterotopia which ...
Regina Vontell +13 more
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High-resolution spatiotemporal analysis of single serotonergic axons in an in vitro system
Frontiers in Neuroscience, 2022 Vertebrate brains have a dual structure, composed of (i) axons that can be well-captured with graph-theoretical methods and (ii) axons that form a dense matrix in which neurons with precise connections operate.
Melissa Hingorani +3 more
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Translational regulation in growth cones [PDF]
Current Opinion in Genetics & Development, 2011 Axonal growth cones (GCs) steer in response to extrinsic cues using mechanisms that include local protein synthesis. This adaptive form of gene regulation occurs with spatial precision and depends on subcellular mRNA localisation. Recent genome-wide studies have shown unexpectedly complex and dynamically changing mRNA repertoires in growing axons and ...
Hosung, Jung +2 more
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Cell Reports, 2017 During brain wiring, cue-induced axon behaviors such as directional steering and branching are aided by localized mRNA translation. Different guidance cues elicit translation of subsets of mRNAs that differentially regulate the cytoskeleton, yet little ...
Anaïs Bellon +14 more
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Frontiers in Molecular Neuroscience, 2021 During the establishment of neural circuitry axons often need to cover long distances to reach remote targets. The stereotyped navigation of these axons defines the connectivity between brain regions and cellular subtypes.
Carlos Sánchez-Huertas, Eloísa Herrera
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