Results 21 to 30 of about 5,264,018 (278)

Cue-Polarized Transport of β-actin mRNA Depends on 3′UTR and Microtubules in Live Growth Cones

Frontiers in Cellular Neuroscience, 2018
Guidance cues trigger fast responses in axonal growth cones such as directional turning and collapse that require local protein synthesis. An attractive cue-gradient, such as Netrin-1, triggers de novo synthesis of β-actin localized to the near-side ...
Kin-Mei Leung, Bo Lu, Hovy Ho-Wai Wong, Julie Qiaojin Lin, Benita Turner-Bridger, Christine E. Holt   +5 more
doaj   +1 more source

To Stick or Not to Stick: The Multiple Roles of Cell Adhesion Molecules in Neural Circuit Assembly

Frontiers in Neuroscience, 2022
Precise wiring of neural circuits is essential for brain connectivity and function. During development, axons respond to diverse cues present in the extracellular matrix or at the surface of other cells to navigate to specific targets, where they ...
Trevor Moreland, Fabienne E. Poulain
doaj   +1 more source

Translational regulation in growth cones [PDF]

Current Opinion in Genetics & Development, 2011
Axonal growth cones (GCs) steer in response to extrinsic cues using mechanisms that include local protein synthesis. This adaptive form of gene regulation occurs with spatial precision and depends on subcellular mRNA localisation. Recent genome-wide studies have shown unexpectedly complex and dynamically changing mRNA repertoires in growing axons and ...
Hosung, Jung, Catherine M, O'Hare, Christine E, Holt   +2 more
openaire   +3 more sources

The Role of Apoptotic Signaling in Axon Guidance

Journal of Developmental Biology, 2018
Navigating growth cones are exposed to multiple signals simultaneously and have to integrate competing cues into a coherent navigational response. Integration of guidance cues is traditionally thought to occur at the level of cytoskeletal dynamics ...
Riley Kellermeyer, Leah M. Heydman, Grant S. Mastick, Thomas Kidd   +3 more
doaj   +1 more source

{alpha}2-Chimaerin, cyclin-dependent kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse [PDF]

, 2004
Neurite outgrowth is influenced by positive and negative signals that include the semaphorins, an important family of axonal outgrowth inhibitors. Here we report that the Rac GTPase activating protein (GAP){alpha}2-chimaerin is involved in Semaphorin 3A (
Eickholt, B, Teo, M, Lim, L, Ferrari, G, Eickholt, Britta, Jacobs, Tom, Leung, Thomas, Jacobs, T., Leung, T., Leung, T, Eickholt, B., Lim, L., Hall, Christine, Qi, R Z, Teo, M., Monfries, C, Jacobs, T, Brown, Matthew, Monfries, Clinton, Teo, Mabel, Qi, Robert Z., Ferrari, G., Qi, R.Z., Lim, Louis, Brown, M., Hall, C., Ferrari, Giovanna, Hall, C, Brown, M, Monfries, C.   +29 more
core   +1 more source

Growth Cones: Structural, Molecular and Functional Relevance to Neuronal Migration, Regeneration and Reproductive Function [PDF]

Journal of Medical Academics
The specialized cells of the human brain form a complex network responsible for neural processing and transmission via various electrochemical signaling pathways.
Mona Sharma, Anmol Garg, Tanya Gupta
doaj   +1 more source

Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2 [PDF]

, 2014
BackgroundIn the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone ...
Sílvia Vieira, Wittmann, Torsten, Sousa, Mónica M., Márcia A Liz, Pimentel, Helena I., Vera F Sousa, Telma E Santos, Vieira, Sílvia, Marques, Ana M., Sutherland, Calum; id_orcid, Hayley Pemble, Liz, Márcia A., Calum Sutherland, Mar, Fernando M., Mónica M Sousa, Pemble, Hayley, Sousa, Vera F., Helena I Pimentel, James R Woodgett, Morgado, Marlene M., Torsten Wittmann, Woodgett, James R., Santos, Telma E., Fernando M Mar, Ana M Marques, Marlene M Morgado   +25 more
core   +1 more source

Transcriptional Control of Axon Guidance at Midline Structures

Frontiers in Cell and Developmental Biology, 2022
The development of the nervous system is a time-ordered and multi-stepped process that includes neurogenesis and neuronal specification, axonal navigation, and circuits assembly.
Eloísa Herrera, Augusto Escalante
doaj   +1 more source

Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons

eLife, 2015
During nervous system development, commissural axons cross the midline despite the presence of repellant ligands. In Drosophila, commissural axons avoid premature responsiveness to the midline repellant Slit by expressing the endosomal sorting receptor ...
Timothy A Evans, Celine Santiago, Elise Arbeille, Greg J Bashaw   +3 more
doaj   +1 more source

High-resolution spatiotemporal analysis of single serotonergic axons in an in vitro system

Frontiers in Neuroscience, 2022
Vertebrate brains have a dual structure, composed of (i) axons that can be well-captured with graph-theoretical methods and (ii) axons that form a dense matrix in which neurons with precise connections operate.
Melissa Hingorani, Adele M. L. Viviani, Jenna E. Sanfilippo, Skirmantas Janušonis   +3 more
doaj   +1 more source