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Frontiers in Cellular NeuroscienceIntroductionCadherin adhesive and actomyosin signaling are key cytomechanical cues required for neuronal circuit formation, but whether they function together to sculpt developing neurons is not known. Previously, we demonstrated that a β-catenin mutant (
Valerie Lew +6 more
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Regulation of growth cone behavior by calcium [PDF]
The Journal of Neuroscience, 1991 Few structures within the nervous system have received more attention than the neuronal growth cone. Initially named by Ramon y Cajal (1890) who recognized its dynamics and importance in histological sections, the growth cone plays essential roles in the development, repair, and modification of neuronal circuitry. Growth cones have a diverse repertoire
S B, Kater, L R, Mills
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Dataset of growth cone-enriched lipidome and proteome of embryonic to early postnatal mouse brain
Data in Brief, 2019 A growth cone is a part of a neuron considered as a hub for axon growth, motility and guidance functions. Growth cones are thought to play a critical role during development of neurons.
Anna Trzeciecka, Sanjoy K. Bhattacharya
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Frontiers in Molecular Neuroscience, 2017 Spontaneous Ca2+ transients and actin dynamics in primary motoneurons correspond to cellular differentiation such as axon elongation and growth cone formation.
Benjamin Dombert +6 more
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Identification of the growth cone as a probe and driver of neuronal migration in the injured brain
Nature CommunicationsAxonal growth cones mediate axonal guidance and growth regulation. We show that migrating neurons in mice possess a growth cone at the tip of their leading process, similar to that of axons, in terms of the cytoskeletal dynamics and functional ...
Chikako Nakajima +27 more
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Filopodial dynamics and growth cone stabilization in Drosophila visual circuit development
eLife, 2015 Filopodial dynamics are thought to control growth cone guidance, but the types and roles of growth cone dynamics underlying neural circuit assembly in a living brain are largely unknown.
Mehmet Neset Özel +3 more
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Neuron, 1995 This study examines the mechanisms of spontaneous and induced [Ca2+]i spiking in nerve growth cones and the effect of spikes on growth cone migration. Over a 10-20 min observation period, 29% of DRG growth cones undergo spontaneous and transient elevations in physiological extracellular Ca2+ ((Ca2+)o; 2 mM), whereas 67% of growth cones exposed to 20 mM
Gomez, Timothy M +2 more
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Homer regulates calcium signalling in growth cone turning
Neural Development, 2009 Background Homer proteins are post-synaptic density proteins with known functions in receptor trafficking and calcium homeostasis. While they are key mediators of synaptic plasticity, they are also known to function in axon guidance, albeit by mechanisms
Thompson Michael JW +4 more
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Syndecan Promotes Axon Regeneration by Stabilizing Growth Cone Migration
Cell Reports, 2014 Growth cones facilitate the repair of nervous system damage by providing the driving force for axon regeneration. Using single-neuron laser axotomy and in vivo time-lapse imaging, we show that syndecan, a heparan sulfate (HS) proteoglycan, is required ...
Tyson J. Edwards, Marc Hammarlund
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Rapid Changes in the Translatome during the Conversion of Growth Cones to Synaptic Terminals
Cell Reports, 2016 Summary: A common step in the formation of neural circuits is the conversion of growth cones to presynaptic terminals. Characterizing patterns of global gene expression during this process is problematic due to the cellular diversity of the brain and the
Kelvin Xi Zhang +4 more
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