Results 41 to 50 of about 5,264,018 (278)

Phosphatase and tensin homolog: A potential target for therapeutic intervention in optic nerve regeneration

Neural Regeneration Research
Recent studies have found that the suppression of phosphatase and tensin homolog is one of the most effective single-gene approaches for promoting optic nerve regeneration.
Bin Tong, Yanzhuo Song, Zhengyang Li, Muhan Cai, Haodong Qi, Kangtai Su, Hong A. Xu   +6 more
doaj   +1 more source

Inhibition of Rho GTPases in Invertebrate Growth Cones Induces a Switch in Responsiveness to Retinoic Acid

Biomolecules, 2019
During development, growth cones are essential for axon pathfinding by sensing numerous guidance cues in their environment. Retinoic acid, the metabolite of vitamin A, is important for neurite outgrowth during vertebrate development, but may also play a ...
Alysha Johnson, Tamara I. N. Nasser, Gaynor E. Spencer   +2 more
doaj   +1 more source

Learning the Biochemical Basis of Axonal Guidance: Using Caenorhabditis elegans as a Model

Biomedicines, 2023
Aim: Experimental models are a powerful aid in visualizing molecular phenomena. This work reports how the worm Caenorhabditis elegans (C. elegans) can be effectively explored for students to learn how molecular cues dramatically condition axonal guidance
Andreia Teixeira-Castro, João Carlos Sousa, Cármen Vieira, Joana Pereira-Sousa, Daniela Vilasboas-Campos, Fernanda Marques, Perpétua Pinto-do-Ó, Patrícia Maciel   +7 more
doaj   +1 more source

Growth cone interactions

, 2011
The tips of growing nerve axons flatten into growth cones, which are responsible for the navigation and elongation of the nerve toward the target. These sequences are of interactions between neurite growth cones dissociated from the sea hare, Aplysia ...
Chi, Hung Lin, Forscher, Paul
core   +2 more sources

Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance

eLife, 2018
Growth cones navigate axonal projection in response to guidance cues. However, it is unclear how they can decide the migratory direction by transducing the local spatial cues into protrusive forces.
Kentarou Baba, Wataru Yoshida, Michinori Toriyama, Tadayuki Shimada, Colleen F Manning, Michiko Saito, Kenji Kohno, James S Trimmer, Rikiya Watanabe, Naoyuki Inagaki   +9 more
doaj   +1 more source

Frataxin Deficit Leads to Reduced Dynamics of Growth Cones in Dorsal Root Ganglia Neurons of Friedreich’s Ataxia YG8sR Model: A Multilinear Algebra Approach

Frontiers in Molecular Neuroscience, 2022
Computational techniques for analyzing biological images offer a great potential to enhance our knowledge of the biological processes underlying disorders of the nervous system. Friedreich’s Ataxia (FRDA) is a rare progressive neurodegenerative inherited
Diana C. Muñoz-Lasso, Belén Mollá, Belén Mollá, Jhon J. Sáenz-Gamboa, Jhon J. Sáenz-Gamboa, Jhon J. Sáenz-Gamboa, Edwin Insuasty, Maria de la Iglesia-Vaya, Maria de la Iglesia-Vaya, Maria de la Iglesia-Vaya, Mark A. Pook, Federico V. Pallardó, Federico V. Pallardó, Federico V. Pallardó, Francesc Palau, Francesc Palau, Francesc Palau, Pilar Gonzalez-Cabo, Pilar Gonzalez-Cabo, Pilar Gonzalez-Cabo   +19 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Retrograde Ret signaling controls sensory pioneer axon outgrowth

eLife, 2019
The trafficking mechanisms and transcriptional targets downstream of long-range neurotrophic factor ligand/receptor signaling that promote axon growth are incompletely understood. Zebrafish carrying a null mutation in a neurotrophic factor receptor, Ret,
Adam Tuttle, Catherine M Drerup, Molly Marra, Hillary McGraw, Alex V Nechiporuk   +4 more
doaj   +1 more source

Roles of dual specificity tyrosine-phosphorylation-regulated kinase 2 in nervous system development and disease

Frontiers in Neuroscience, 2022
Dual specificity tyrosine-phosphorylation-regulated kinases (DYRKs) are a group of conserved eukaryotic kinases phosphorylating tyrosine, serine, and threonine residues. The human DYRK family comprises 5 members (DYRK1A, DYRK1B, DYRK2, DYRK3, and DYRK4).
Gabriel Nicolás Santos-Durán, Antón Barreiro-Iglesias   +1 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source