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Mechanisms of growth cone repulsion [PDF]
F1000 Biology Reports, 2010 Research conducted in the last century suggested that chemoattractants guide cells or their processes to appropriate locations during development. Today, we know that many of the molecules involved in cellular guidance can act as chemorepellents that prevent migration into inappropriate territories. Here, we review some of the early seminal experiments
Krull, Catherine E, Eisen, Judith S
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Frontiers in Physiology, 2019 Cytoplasmic Actin Gamma 1 (ACTG1) gene variant are autosomal dominant and can cause CNS anomalies (Baraitser Winter Malformation Syndrome; BWMS). ACTG1 anomalies in offspring include agenesis of the corpus callosum (ACC) and neuronal heterotopia which ...
Regina Vontell +13 more
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Frontiers in Molecular Neuroscience, 2021 During the establishment of neural circuitry axons often need to cover long distances to reach remote targets. The stereotyped navigation of these axons defines the connectivity between brain regions and cellular subtypes.
Carlos Sánchez-Huertas, Eloísa Herrera
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Cell Reports, 2017 During brain wiring, cue-induced axon behaviors such as directional steering and branching are aided by localized mRNA translation. Different guidance cues elicit translation of subsets of mRNAs that differentially regulate the cytoskeleton, yet little ...
Anaïs Bellon +14 more
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Growth cone-growth cone interactions in cultures of rat sympathetic neurons
Developmental Biology, 1989 Growth cones of sympathetic neurons from the superior cervical ganglia of neonatal rats were studied using video-microscopy to determine events following contact between growth cones and other cell surfaces, including other growth cones and neurites. A variety of behaviors were observed to occur upon contact between growth cones.
J K, Ivins, R N, Pittman
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, 2016 The tips of growing nerve axons flatten into growth cones, which are responsible for the navigation and elongation of the nerve toward the target. These sequences are of interactions between neurite growth cones dissociated from the sea hare, Aplysia ...
Chi, Hung Lin, Forscher, Paul
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Frontiers in Neural Circuits, 2020 Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates local translation in dendrites and spines for synaptic plasticity. In axons, FMRP is implicated in axonal extension and axon guidance.
Masaru Takabatake +2 more
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Neuronal Growth Cone Size-Dependent and -Independent Parameters of Microtubule Polymerization
Frontiers in Cellular Neuroscience, 2018 Migration and pathfinding of neuronal growth cones during neurite extension is critically dependent on dynamic microtubules. In this study we sought to determine, which aspects of microtubule polymerization relate to growth cone morphology and migratory ...
Alexa Kiss +4 more
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Neural Development, 2009 Background While many molecules involved in axon guidance have been identified, the cellular and molecular mechanisms by which these molecules regulate growth cone morphology during axon outgrowth remain to be elucidated.
Lundquist Erik A +2 more
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Optically guided neuronal growth [PDF]
, 2011 In this thesis, experiments into artificially guiding neuronal growth cones using tightly focused laser beams were performed and evaluated. The experiments are performed by focusing a laser beam to the leading edge of a developing growth cone and ...
Carnegie, David John
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