Results 31 to 40 of about 97,079 (259)

Growth cone-growth cone interactions in cultures of rat sympathetic neurons

Developmental Biology, 1989
Growth cones of sympathetic neurons from the superior cervical ganglia of neonatal rats were studied using video-microscopy to determine events following contact between growth cones and other cell surfaces, including other growth cones and neurites. A variety of behaviors were observed to occur upon contact between growth cones.
J K, Ivins, R N, Pittman
openaire   +2 more sources

Neuronal Growth Cone Size-Dependent and -Independent Parameters of Microtubule Polymerization

Frontiers in Cellular Neuroscience, 2018
Migration and pathfinding of neuronal growth cones during neurite extension is critically dependent on dynamic microtubules. In this study we sought to determine, which aspects of microtubule polymerization relate to growth cone morphology and migratory ...
Alexa Kiss, Irmgard Fischer, Tatjana Kleele, Thomas Misgeld, Friedrich Propst   +4 more
doaj   +1 more source

Semaphorin-3A Promotes Degradation of Fragile X Mental Retardation Protein in Growth Cones via the Ubiquitin-Proteasome Pathway

Frontiers in Neural Circuits, 2020
Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates local translation in dendrites and spines for synaptic plasticity. In axons, FMRP is implicated in axonal extension and axon guidance.
Masaru Takabatake, Yoshio Goshima, Yukio Sasaki   +2 more
doaj   +1 more source

The Arp2/3 complex, UNC-115/abLIM, and UNC-34/Enabled regulate axon guidance and growth cone filopodia formation in Caenorhabditis elegans

Neural Development, 2009
Background While many molecules involved in axon guidance have been identified, the cellular and molecular mechanisms by which these molecules regulate growth cone morphology during axon outgrowth remain to be elucidated.
Lundquist Erik A, Dyer Jamie O, Norris Adam D   +2 more
doaj   +1 more source

Inhibition of Rho GTPases in Invertebrate Growth Cones Induces a Switch in Responsiveness to Retinoic Acid

Biomolecules, 2019
During development, growth cones are essential for axon pathfinding by sensing numerous guidance cues in their environment. Retinoic acid, the metabolite of vitamin A, is important for neurite outgrowth during vertebrate development, but may also play a ...
Alysha Johnson, Tamara I. N. Nasser, Gaynor E. Spencer   +2 more
doaj   +1 more source

Learning the Biochemical Basis of Axonal Guidance: Using Caenorhabditis elegans as a Model

Biomedicines, 2023
Aim: Experimental models are a powerful aid in visualizing molecular phenomena. This work reports how the worm Caenorhabditis elegans (C. elegans) can be effectively explored for students to learn how molecular cues dramatically condition axonal guidance
Andreia Teixeira-Castro, João Carlos Sousa, Cármen Vieira, Joana Pereira-Sousa, Daniela Vilasboas-Campos, Fernanda Marques, Perpétua Pinto-do-Ó, Patrícia Maciel   +7 more
doaj   +1 more source

Filopodial dynamics and growth cone stabilization in Drosophila visual circuit development

eLife, 2015
Filopodial dynamics are thought to control growth cone guidance, but the types and roles of growth cone dynamics underlying neural circuit assembly in a living brain are largely unknown.
Mehmet Neset Özel, Marion Langen, Bassem A Hassan, P Robin Hiesinger   +3 more
doaj   +1 more source

Frataxin Deficit Leads to Reduced Dynamics of Growth Cones in Dorsal Root Ganglia Neurons of Friedreich’s Ataxia YG8sR Model: A Multilinear Algebra Approach

Frontiers in Molecular Neuroscience, 2022
Computational techniques for analyzing biological images offer a great potential to enhance our knowledge of the biological processes underlying disorders of the nervous system. Friedreich’s Ataxia (FRDA) is a rare progressive neurodegenerative inherited
Diana C. Muñoz-Lasso, Belén Mollá, Belén Mollá, Jhon J. Sáenz-Gamboa, Jhon J. Sáenz-Gamboa, Jhon J. Sáenz-Gamboa, Edwin Insuasty, Maria de la Iglesia-Vaya, Maria de la Iglesia-Vaya, Maria de la Iglesia-Vaya, Mark A. Pook, Federico V. Pallardó, Federico V. Pallardó, Federico V. Pallardó, Francesc Palau, Francesc Palau, Francesc Palau, Pilar Gonzalez-Cabo, Pilar Gonzalez-Cabo, Pilar Gonzalez-Cabo   +19 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Phosphatase and tensin homolog: A potential target for therapeutic intervention in optic nerve regeneration

Neural Regeneration Research
Recent studies have found that the suppression of phosphatase and tensin homolog is one of the most effective single-gene approaches for promoting optic nerve regeneration.
Bin Tong, Yanzhuo Song, Zhengyang Li, Muhan Cai, Haodong Qi, Kangtai Su, Hong A. Xu   +6 more
doaj   +1 more source