Results 31 to 40 of about 97,613 (259)
Growth cone-growth cone interactions in cultures of rat sympathetic neurons
Developmental Biology, 1989 Growth cones of sympathetic neurons from the superior cervical ganglia of neonatal rats were studied using video-microscopy to determine events following contact between growth cones and other cell surfaces, including other growth cones and neurites. A variety of behaviors were observed to occur upon contact between growth cones.
J K, Ivins, R N, Pittman
openaire +2 more sources
Frontiers in Neural Circuits, 2020 Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates local translation in dendrites and spines for synaptic plasticity. In axons, FMRP is implicated in axonal extension and axon guidance.
Masaru Takabatake +2 more
doaj +1 more source
Neuronal Growth Cone Size-Dependent and -Independent Parameters of Microtubule Polymerization
Frontiers in Cellular Neuroscience, 2018 Migration and pathfinding of neuronal growth cones during neurite extension is critically dependent on dynamic microtubules. In this study we sought to determine, which aspects of microtubule polymerization relate to growth cone morphology and migratory ...
Alexa Kiss +4 more
doaj +1 more source
Neural Development, 2009 Background While many molecules involved in axon guidance have been identified, the cellular and molecular mechanisms by which these molecules regulate growth cone morphology during axon outgrowth remain to be elucidated.
Lundquist Erik A +2 more
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Neural Regeneration ResearchRecent studies have found that the suppression of phosphatase and tensin homolog is one of the most effective single-gene approaches for promoting optic nerve regeneration.
Bin Tong +6 more
doaj +1 more source
Biomolecules, 2019 During development, growth cones are essential for axon pathfinding by sensing numerous guidance cues in their environment. Retinoic acid, the metabolite of vitamin A, is important for neurite outgrowth during vertebrate development, but may also play a ...
Alysha Johnson +2 more
doaj +1 more source
Learning the Biochemical Basis of Axonal Guidance: Using Caenorhabditis elegans as a Model
Biomedicines, 2023 Aim: Experimental models are a powerful aid in visualizing molecular phenomena. This work reports how the worm Caenorhabditis elegans (C. elegans) can be effectively explored for students to learn how molecular cues dramatically condition axonal guidance
Andreia Teixeira-Castro +7 more
doaj +1 more source
Gradient-reading and mechano-effector machinery for netrin-1-induced axon guidance
eLife, 2018 Growth cones navigate axonal projection in response to guidance cues. However, it is unclear how they can decide the migratory direction by transducing the local spatial cues into protrusive forces.
Kentarou Baba +9 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 Computational techniques for analyzing biological images offer a great potential to enhance our knowledge of the biological processes underlying disorders of the nervous system. Friedreich’s Ataxia (FRDA) is a rare progressive neurodegenerative inherited
Diana C. Muñoz-Lasso +19 more
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Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source