Results 31 to 40 of about 902,976 (291)
Structural Perspectives on Axon Guidance
Annual Review of Cell and Developmental Biology, 2016 Axon guidance relies on a combinatorial code of receptor and ligand interactions that direct adhesive/attractive and repulsive cellular responses. Recent structural data have revealed many of the molecular mechanisms that govern these interactions and enabled the design of sophisticated mutant tools to dissect their biological functions.
Seiradake, E., Jones, E., Klein, R.
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Signaling from Axon Guidance Receptors [PDF]
, 2010 Determining how axon guidance receptors transmit signals to allow precise pathfinding decisions is fundamental to our understanding of nervous system development and may suggest new strategies to promote axon regeneration after injury or disease ...
Bashaw, G. J., Bashaw, G., Klein, R.
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The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance
Cell Reports, 2019 Summary: The small GTPase Arl13b is enriched in primary cilia and regulates Sonic hedgehog (Shh) signaling. During neural development, Shh controls patterning and proliferation through a canonical, transcription-dependent pathway that requires the ...
Julien Ferent +8 more
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PLoS Genetics, 2015 During development, axons must integrate directional information encoded by multiple guidance cues and their receptors. Axon guidance receptors, such as UNC-40 (DCC) and SAX-3 (Robo), can function individually or combinatorially with other guidance ...
Yan Xu +3 more
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Frontiers in Molecular Neuroscience, 2021 During the establishment of neural circuitry axons often need to cover long distances to reach remote targets. The stereotyped navigation of these axons defines the connectivity between brain regions and cellular subtypes.
Carlos Sánchez-Huertas, Eloísa Herrera
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The impact of career guidance on progression in learning and work: a literature review [PDF]
, 2016 This paper sets out the findings of a review of the literature on how career guidance can support individuals to progress to positive learning and work destinations.
Neary, S. +3 more
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Microfluidic control of axonal guidance [PDF]
Scientific Reports, 2014 The precision of axonal pathfinding and the accurate formation of functional neural circuitry are crucial for an organism during development as well as during adult central and peripheral nerve regeneration. While chemical cues are believed to be primarily responsible for axonal pathfinding, we hypothesize that forces due to localized fluid flow may ...
Gu, Ling +5 more
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Axon guidance molecules in immunometabolic diseases
Inflammation and Regeneration, 2022 The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions.
Yoshimitsu Nakanishi +2 more
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Research progress of acupuncture and moxibustion on axon guidance cues
针刺研究, 2020 Axon guidance cues includes Slit, Semaphorin, Ephrin and Netrin. They have the function of regulating the regeneration of axons and guiding the regenerated axons to the correct target.
SONG Yang-yang, XU Wen-tao, NI Guang-xia
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Cannabinoid receptor CB2 modulates axon guidance. [PDF]
PLoS ONE, 2013 Navigation of retinal projections towards their targets is regulated by guidance molecules and growth cone transduction mechanisms. Here, we present in vitro and in vivo evidences that the cannabinoid receptor 2 (CB2R) is expressed along the retino ...
Gabriel Duff +8 more
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