Results 31 to 40 of about 1,064,643 (248)
Understanding axon guidance: are we nearly there yet?
Development, 2018 During nervous system development, neurons extend axons to reach their targets and form functional circuits. The faulty assembly or disintegration of such circuits results in disorders of the nervous system.
E. Stoeckli
semanticscholar +1 more source
Independent signaling by Drosophila insulin receptor for axon guidance and growth
Frontiers in Physiology, 2014 The Drosophila insulin receptor (DInR) regulates a diverse array of biological processes including growth, axon guidance, and sugar homeostasis. Growth regulation by DInR is mediated by Chico, the Drosophila homolog of vertebrate insulin-receptor ...
Caroline Rita Li +2 more
doaj +1 more source
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Nature, 2012 Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively accrued clinical cohort (n = 142) of early (stage I and II) sporadic ...
A. Biankin +125 more
semanticscholar +1 more source
Where does axon guidance lead us? [version 1; referees: 2 approved]
F1000Research, 2017 During neural circuit formation, axons need to navigate to their target cells in a complex, constantly changing environment. Although we most likely have identified most axon guidance cues and their receptors, we still cannot explain the molecular ...
Esther Stoeckli
doaj +1 more source
Frontiers in Molecular Neuroscience, 2021 During the establishment of neural circuitry axons often need to cover long distances to reach remote targets. The stereotyped navigation of these axons defines the connectivity between brain regions and cellular subtypes.
Carlos Sánchez-Huertas, Eloísa Herrera
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Axon Guidance Molecules Guiding Neuroinflammation
Experimental Neurobiology, 2019 Axon guidance molecules (AGMs), such as Netrins, Semaphorins, and Ephrins, have long been known to regulate axonal growth in the developing nervous system. Interestingly, the chemotactic properties of AGMs are also important in the postnatal period, such
Won Suk Lee, Won-Ha Lee, Y. Bae, K. Suk
semanticscholar +1 more source
PLoS Genetics, 2015 During development, axons must integrate directional information encoded by multiple guidance cues and their receptors. Axon guidance receptors, such as UNC-40 (DCC) and SAX-3 (Robo), can function individually or combinatorially with other guidance ...
Yan Xu +3 more
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Axon guidance molecules in immunometabolic diseases
Inflammation and Regeneration, 2022 The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions.
Yoshimitsu Nakanishi +2 more
doaj +1 more source
The Role of Apoptotic Signaling in Axon Guidance
Journal of Developmental Biology, 2018 Navigating growth cones are exposed to multiple signals simultaneously and have to integrate competing cues into a coherent navigational response. Integration of guidance cues is traditionally thought to occur at the level of cytoskeletal dynamics ...
Riley Kellermeyer +3 more
doaj +1 more source
TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation
Cell Reports, 2020 Summary: Neuronal migration, axon fasciculation, and axon guidance need to be closely coordinated for neural circuit assembly. Spinal motor neurons (MNs) face unique challenges during development because their cell bodies reside within the central ...
Tracey A.C.S. Suter +5 more
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