Results 51 to 60 of about 1,064,643 (248)

Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin

eLife, 2019
Developing neurons of the peripheral nervous system reach their targets via cues that support directional growth, a process known as axon guidance.
Denise M Poltavski, Pauline Colombier, Jianxin Hu, Alicia Duron, Brian L Black, Takako Makita   +5 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

The role of axon guidance molecules in the pathogenesis of epilepsy

Neural Regeneration Research
Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms
Zheng Liu, Chunhua Pan, Hao Huang
doaj   +1 more source

Netrin1 produced by neural progenitors, not floor plate cells, is required for axon guidance in the spinal cord

Neuron, 2017
SUMMARY Netrin1 has been proposed to act from the floor plate (FP) as a long-range diffusible chemoattractant for commissural axons in the embryonic spinal cord.
Supraja G. Varadarajan, Jennifer H. Kong, Keith D. Phan, Tzu-Jen Kao, S. Panaitof, J. Cardin, H. Eltzschig, Artur Kania, Artur Kania, Bennett G. Novitch, S. Butler   +10 more
semanticscholar   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Exosomes: new targets for understanding axon guidance in the developing central nervous system

Frontiers in Cell and Developmental Biology
Axon guidance is a key event in neural circuit development that drives the correct targeting of axons to their targets through long distances and unique patterns.
Mingyu Liu, Mingyu Liu, Teng Teng, Teng Teng, Teng Teng   +4 more
doaj   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Delta protocadherin 10 is regulated by activity in the mouse main olfactory system

Frontiers in Neural Circuits, 2011
Olfactory sensory neurons (OSNs) are thought to use activity-dependent and independent mechanisms to regulate the expression of axon guidance genes. However, defining the molecular mechanisms that underlie activity-dependent OSN guidance has remained ...
Eric O Williams, Heather M Sickles, Alison L Dooley, Sierra ePalumbos, Adam J Bisogni, David M Lin   +5 more
doaj   +1 more source

Anti‐CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos, Marwa Al‐Dubai, Denise Walther, Dominic Borie, Jan D. Lünemann, Marc Pawlitzki, Sven G. Meuth, Solveig Henneicke, Stefan Vielhaber, Stefanie Schreiber   +9 more
wiley   +1 more source

Extracellular matrix regulates UNC-6 (netrin) axon guidance by controlling the direction of intracellular UNC-40 (DCC) outgrowth activity. [PDF]

PLoS ONE, 2014
How extracellular molecules influence the direction of axon guidance is poorly understood. The HSN axon of Caenorhabditis elegans is guided towards a ventral source of secreted UNC-6 (netrin). The axon's outgrowth response to UNC-6 is mediated by the UNC-
Yong Yang, Won Suk Lee, Xia Tang, William G Wadsworth   +3 more
doaj   +1 more source