Results 61 to 70 of about 902,976 (291)

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Molecular regulation of axon termination in mechanosensory neurons [PDF]

Spatially and temporally accurate termination of axon outgrowth, a process called axon termination, is required for efficient, precise nervous system construction and wiring.
Desbois, Muriel, Grill, Brock
core   +1 more source

Effective Policy Frameworks for the Organisation of Career Guidance Services A Review of the Literature [PDF]

, 2015
This paper focuses on how public policy shapes career guidance and establishes a system within which individuals can access career support. Governments are critical to career guidance primarily as funders of the activity, but also importantly as ...
Neary, S., Mackay, Susan, Hooley, Tristram, Morris, Marian   +3 more
core   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Axon guidance by targeted photoacoustic stimulation [PDF]

, 2022
Repairing injured nervous systems requires the ability to regenerate axons and to guide growing axons to their targets. To achieve guidance, mechanistic studies in physiological axon guidance in developing neurons will be critical.
Rosen, Gavin
core   +1 more source

Delta protocadherin 10 is regulated by activity in the mouse main olfactory system

Frontiers in Neural Circuits, 2011
Olfactory sensory neurons (OSNs) are thought to use activity-dependent and independent mechanisms to regulate the expression of axon guidance genes. However, defining the molecular mechanisms that underlie activity-dependent OSN guidance has remained ...
Eric O Williams, Heather M Sickles, Alison L Dooley, Sierra ePalumbos, Adam J Bisogni, David M Lin   +5 more
doaj   +1 more source

Extracellular matrix regulates UNC-6 (netrin) axon guidance by controlling the direction of intracellular UNC-40 (DCC) outgrowth activity. [PDF]

PLoS ONE, 2014
How extracellular molecules influence the direction of axon guidance is poorly understood. The HSN axon of Caenorhabditis elegans is guided towards a ventral source of secreted UNC-6 (netrin). The axon's outgrowth response to UNC-6 is mediated by the UNC-
Yong Yang, Won Suk Lee, Xia Tang, William G Wadsworth   +3 more
doaj   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Lbx1-expressing cells lacking the repellent EphA4 receptor are involved in axonal midline crossing in the spinal cord and evoke a minor gait defect [PDF]

, 2014
Most limbed animals, including mice and human beings, show alternating hindlimb movement mediated by neuronal circuits in the spinal cord. However, when the repulsive EphA4 receptor expressed by subsets of spinal neurons is mutated, hindlimbs lose ...
Pudenz, Christiane
core   +1 more source

Microtubule dynamics in axon guidance [PDF]

Neuroscience Bulletin, 2014
Precise modulation of the cytoskeleton is involved in a variety of cellular processes including cell division, migration, polarity, and adhesion. In developing post-mitotic neurons, extracellular guidance cues not only trigger signaling cascades that act at a distance to indirectly regulate microtubule distribution, and assembly and disassembly in the ...
Guofa, Liu, Trisha, Dwyer
openaire   +2 more sources