Results 11 to 20 of about 1,064,643 (248)
microRNAs in axon guidance [PDF]
Frontiers in Cellular Neuroscience, 2014 Brain wiring is a highly intricate process in which trillions of neuronal connections are established. Its initial phase is particularly crucial in establishing the general framework of neuronal circuits.
Archana N Iyer +2 more
doaj +3 more sources
Glycosylation in Axonal Guidance [PDF]
International Journal of Molecular Sciences, 2021 How millions of axons navigate accurately toward synaptic targets during development is a long-standing question. Over decades, multiple studies have enriched our understanding of axonal pathfinding with discoveries of guidance molecules and morphogens, their receptors, and downstream signalling mechanisms.
Sampada P. Mutalik, Stephanie L. Gupton
openaire +2 more sources
Theory for Durotactic Axon Guidance [PDF]
Physical Review Letters, 2021 During the development of the nervous system, neurons extend bundles of axons that grow and meet other neurons to form the neuronal network. Robust guidance mechanisms are needed for these bundles to migrate and reach their functional target. Directional information depends on external cues such as chemical or mechanical gradients.
Oliveri, Hadrien +2 more
openaire +3 more sources
Structural Perspectives on Axon Guidance.
Annual Review of Cell and Developmental Biology, 2016 Axon guidance relies on a combinatorial code of receptor and ligand interactions that direct adhesive/attractive and repulsive cellular responses. Recent structural data have revealed many of the molecular mechanisms that govern these interactions and enabled the design of sophisticated mutant tools to dissect their biological functions.
E. Seiradake, E. Jones, R. Klein
semanticscholar +5 more sources
Frontiers in Neuroanatomy, 2021 Axon guidance proteins play key roles in the formation of neural circuits during development. We previously identified an axon guidance cue, named draxin, that has no homology with other axon guidance proteins.
Giasuddin Ahmed, Yohei Shinmyo
doaj +1 more source
New insights into the molecular mechanisms of axon guidance receptor regulation and signaling.
Current Topics in Developmental Biology, 2021 As the nervous system develops, newly differentiated neurons need to extend their axons toward their synaptic targets to form functional neural circuits.
Yixin Zang +2 more
semanticscholar +1 more source
Endoglycan plays a role in axon guidance by modulating cell adhesion
eLife, 2021 Axon navigation depends on the interactions between guidance molecules along the trajectory and specific receptors on the growth cone. However, our in vitro and in vivo studies on the role of Endoglycan demonstrate that in addition to specific guidance ...
Thomas Baeriswyl +11 more
doaj +1 more source
Axon Guidance Molecules and Pain
Cells, 2022 Chronic pain is a debilitating condition that influences the social, economic, and psychological aspects of patients’ lives. Hence, the need for better treatment is drawing extensive interest from the research community.
Elisa Damo, Manuela Simonetti
doaj +1 more source
Beyond Axon Guidance: Roles of Slit-Robo Signaling in Neocortical Formation
Frontiers in Cell and Developmental Biology, 2020 The formation of the neocortex relies on intracellular and extracellular signaling molecules that are involved in the sequential steps of corticogenesis, ranging from the proliferation and differentiation of neural progenitor cells to the migration and ...
Y. Gonda +2 more
semanticscholar +1 more source