Results 11 to 20 of about 902,976 (291)
Current Opinion in Neurobiology, 2006 Our knowledge about molecular mechanisms underlying axon guidance along the antero-posterior axis in contrast to the dorso-ventral axis of the developing nervous system is very limited.
Stoeckli, E T; https://orcid.org/
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, 2012 The establishment of complex neuronal circuits is critically dependent on axon guidance. The function of differentiated neurons is predicated on correct axon guidance, and is usually distinguished from the subsequent developmental stages of target ...
Michael J Piper +5 more
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Translating Axon Guidance Cues [PDF]
Cell, 2002 Recent studies suggest that local translation of mRNA within axons plays a key role in two aspects of growth cone navigation. One line of evidence implies a local synthesis of proteins that mediate growth cone collapse and turning in response to guidance
Steward, Oswald
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The Role of Apoptotic Signaling in Axon Guidance [PDF]
Journal of Developmental Biology, 2018 Navigating growth cones are exposed to multiple signals simultaneously and have to integrate competing cues into a coherent navigational response. Integration of guidance cues is traditionally thought to occur at the level of cytoskeletal dynamics ...
Riley Kellermeyer +3 more
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Glycosylation in Axonal Guidance [PDF]
International Journal of Molecular Sciences, 2021 How millions of axons navigate accurately toward synaptic targets during development is a long-standing question. Over decades, multiple studies have enriched our understanding of axonal pathfinding with discoveries of guidance molecules and morphogens, their receptors, and downstream signalling mechanisms.
Sampada P. Mutalik, Stephanie L. Gupton
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Theory for Durotactic Axon Guidance [PDF]
Physical Review Letters, 2021 During the development of the nervous system, neurons extend bundles of axons that grow and meet other neurons to form the neuronal network. Robust guidance mechanisms are needed for these bundles to migrate and reach their functional target. Directional information depends on external cues such as chemical or mechanical gradients.
Oliveri, Hadrien +2 more
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Commissural Axon Kinetics and the Role of Netrin in Early Brain Circuitry Development [PDF]
, 2005 As neurons begin to differentiate, they send out processes called axons to initiate the formation of functional nerve connections. A specialized structure at the end of an axon called the growth cone is believed to possess the impressive navigational and
Bak-Maier, Magdalena
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Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells [PDF]
, 2008 Neuropilin (NRP) receptors and their class 3 semaphorin (SEMA3) ligands play well-established roles in axon guidance, with loss of NRP1, NRP2, SEMA3A or SEMA3F causing defasciculation and errors in growth cone guidance of peripherally projecting nerves ...
Howard, Beatrice +19 more
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Development of the early axon scaffold in the rostral brain of the small spotted cat shark (Scyliorhinus canicula) embryo [PDF]
, 2014 International audienceThe cat shark is increasingly used as a model for Chondrichthyes, an evolutionarily important sister group of the bony vertebrates that include teleosts and tetrapods.
Waring, Colin P. +4 more
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The midline protein regulates axon guidance by blocking the reiteration of neuroblast rows within the Drosophila ventral nerve cord. [PDF]
PLoS Genetics, 2013 Guiding axon growth cones towards their targets is a fundamental process that occurs in a developing nervous system. Several major signaling systems are involved in axon-guidance, and disruption of these systems causes axon-guidance defects. However, the
Mary Ann Manavalan +2 more
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