Results 31 to 40 of about 304,829 (369)
The impact of realistic axonal shape on axon diameter estimation using diffusion MRI [PDF]
, 2020 To study axonal microstructure with diffusion MRI, axons are typically modeled as straight impermeable cylinders, whereby the transverse diffusion MRI signal can be made sensitive to the cylinder's inner diameter. However, the shape of a real axon varies along the axon direction, which couples the longitudinal and transverse diffusion of the overall ...
arxiv +1 more source
Frontiers in Aging Neuroscience, 2019 Alzheimer’s disease (AD), the most common tauopathy, is an age-dependent, progressive neurodegenerative disease. Epidemiological studies implicate the role of genetic background in the onset and progression of AD.
Tomas Smolek +11 more
doaj +1 more source
Non-Canonical Roles of Apoptotic Caspases in the Nervous System
Frontiers in Cell and Developmental Biology, 2022 Caspases are a family of cysteine proteases that predominantly cleave their substrates after aspartic acid residues. Much of what we know of caspases emerged from investigation a highly conserved form of programmed cell death called apoptosis.
Mahshid H. Dehkordi +2 more
doaj +1 more source
microRNAs in axon guidance [PDF]
Frontiers in Cellular Neuroscience, 2014 Brain wiring is a highly intricate process in which trillions of neuronal connections are established. Its initial phase is particularly crucial in establishing the general framework of neuronal circuits. During this early step, differentiating neurons extend axons, which reach their target by navigating through a complex environment with extreme ...
Iyer, A. N., Bellon, A., Baudet, M. L.
openaire +3 more sources
Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
Nature Communications, 2018 Mounting evidence suggests that neuronal activity influences myelination, potentially allowing for experience-driven modulation of neural circuitry. The degree to which neuronal activity is capable of regulating myelination at the individual axon level ...
S. Mitew +11 more
semanticscholar +1 more source
SARM1 Suppresses Axon Branching Through Attenuation of Axonal Cytoskeletal Dynamics
Frontiers in Molecular Neuroscience, 2022 Axon branching is a fundamental aspect of neuronal morphogenesis, neuronal circuit formation, and response of the nervous system to injury. Sterile alpha and TIR motif containing 1 (SARM1) was initially identified as promoting Wallerian degeneration of ...
Andrea Ketschek +3 more
doaj +1 more source
Mechanosensing is critical for axon growth in the developing brain
Nature Neuroscience, 2016 During nervous system development, neurons extend axons along well-defined pathways. The current understanding of axon pathfinding is based mainly on chemical signaling.
David E. Koser +11 more
semanticscholar +1 more source
Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead
Frontiers in Neuroscience, 2018 Neurofibrillary pathology comprised of pathological tau protein is closely tied to a range of neurodegenerative disorders, the most common of which is Alzheimer’s disease.
Petr Novak +7 more
doaj +1 more source
Orchestration of Ion Channels and Transporters in Neocortical Development and Neurological Disorders
Frontiers in Neuroscience, 2022 Electrical activity plays crucial roles in neural circuit formation and remodeling. During neocortical development, neurons are generated in the ventricular zone, migrate to their correct position, elongate dendrites and axons, and form synapses. In this
Yuki Bando +4 more
doaj +1 more source
Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
Science, 2008 The failure of axons to regenerate is a major obstacle for functional recovery after central nervous system (CNS) injury. Removing extracellular inhibitory molecules results in limited axon regeneration in vivo.
Kevin K. Park +10 more
semanticscholar +1 more source