Results 11 to 20 of about 282,607 (316)
, 2010 The formidable task of accurately establishing the connections of the central nervous system appears to be conserved throughout phylogeny as most of the key molecules that mediate the formation of the nervous system are found in organisms separated by ...
Piper, M. +3 more
core +4 more sources
Physiological Reviews, 2011 International audienceAxons are generally considered as reliable transmission cables in which stable propagation occurs once an action potential is generated.
Gisèle Alcaraz +9 more
core +4 more sources
Axonal transport during injury on a theoretical axon
Frontiers in Cellular Neuroscience, 2023 Neurodevelopment, plasticity, and cognition are integral with functional directional transport in neuronal axons that occurs along a unique network of discontinuous polar microtubule (MT) bundles. Axonopathies are caused by brain trauma and genetic diseases that perturb or disrupt the axon MT infrastructure and, with it, the dynamic interplay of motor ...
Soumyadeep Chandra +6 more
openaire +3 more sources
Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2 [PDF]
, 2014 BackgroundIn the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone ...
Sílvia Vieira +25 more
core +1 more source
Pharmacy, 2023 This study aimed to assess third-year student pharmacists’ perspectives regarding a virtually delivered research proposal course. A 23-item questionnaire was distributed to third-year student pharmacists enrolled in a research proposal course over three ...
David R. Axon
doaj +1 more source
Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead
Frontiers in Neuroscience, 2018 Neurofibrillary pathology comprised of pathological tau protein is closely tied to a range of neurodegenerative disorders, the most common of which is Alzheimer’s disease.
Petr Novak +7 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2019 Alzheimer’s disease (AD), the most common tauopathy, is an age-dependent, progressive neurodegenerative disease. Epidemiological studies implicate the role of genetic background in the onset and progression of AD.
Tomas Smolek +11 more
doaj +1 more source
Axon degeneration: Linking axonal bioenergetics to myelin [PDF]
Journal of Cell Biology, 2016 The mechanisms by which axonal degeneration occurs, even in the presence of apparently normal myelin sheaths, remain unknown. In this issue, Yin et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607099) study mutant mice in which proteolipid protein is replaced by the peripheral myelin protein P0 and describe a number of early axonal ...
Beirowski, Bogdan +2 more
openaire +2 more sources
Intersection of pathological tau and microglia at the synapse
Acta Neuropathologica Communications, 2019 Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of aggregated tau and include diseases such as Alzheimer’s disease (AD), progressive supranuclear palsy and chronic traumatic encephalopathy.
Thomas Vogels +2 more
doaj +1 more source