Results 11 to 20 of about 250,866 (269)
Physiological Reviews, 2011 Axons are generally considered as reliable transmission cables in which stable propagation occurs once an action potential is generated. Axon dysfunction occupies a central position in many inherited and acquired neurological disorders that affect both peripheral and central neurons.
Debanne, Dominique +4 more
openaire +3 more sources
Axonal transport during injury on a theoretical axon
Frontiers in Cellular Neuroscience, 2023 Neurodevelopment, plasticity, and cognition are integral with functional directional transport in neuronal axons that occurs along a unique network of discontinuous polar microtubule (MT) bundles. Axonopathies are caused by brain trauma and genetic diseases that perturb or disrupt the axon MT infrastructure and, with it, the dynamic interplay of motor ...
Soumyadeep Chandra +6 more
openaire +3 more sources
Intersection of pathological tau and microglia at the synapse
Acta Neuropathologica Communications, 2019 Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of aggregated tau and include diseases such as Alzheimer’s disease (AD), progressive supranuclear palsy and chronic traumatic encephalopathy.
Thomas Vogels +2 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2019 Alzheimer’s disease (AD), the most common tauopathy, is an age-dependent, progressive neurodegenerative disease. Epidemiological studies implicate the role of genetic background in the onset and progression of AD.
Tomas Smolek +11 more
doaj +1 more source
Axon degeneration: Linking axonal bioenergetics to myelin [PDF]
Journal of Cell Biology, 2016 The mechanisms by which axonal degeneration occurs, even in the presence of apparently normal myelin sheaths, remain unknown. In this issue, Yin et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607099) study mutant mice in which proteolipid protein is replaced by the peripheral myelin protein P0 and describe a number of early axonal ...
Beirowski, Bogdan +2 more
openaire +2 more sources
Determination of immunogenic proteins in biopharmaceuticals by UHPLC–MS amino acid analysis
BMC Chemistry, 2019 Nowadays, there is a growing interest in innovative and more efficient therapeutics—biopharmaceuticals, based on peptides or proteins. There are increased demands on quality control of such therapeutics.
Juraj Piestansky +4 more
doaj +1 more source
Epitafio per Timocrito caduto contro gli Etoli
Axon, 2023 L’iscrizione metrica, scoperta a Tirreo in Acarnania e trascritta da un abitante del luogo, è risultata immediatamente irreperibile. Il testo narra le gesta eroiche del soldato Timocrito, caduto in uno scontro con gli Etoli; nel distico elegiaco ...
Marucci, Marta
doaj +1 more source
Inscription from Caria Mentioning Antiochus III, Ptolemy V, and Philip V
Axon, 2023 The ‘Three Kings’ Inscription’ bears the fragment of a Rhodian arbitration between Bargylia and another town in Caria. It is an important document, for it described major political events which affected western Caria on the eve of the Second ...
Rossini, Alessandro
doaj +1 more source
Axonal Odorant Receptors Mediate Axon Targeting [PDF]
Cell Reports, 2019 In mammals, odorant receptors not only detect odors but also define the target in the olfactory bulb, where sensory neurons project to give rise to the sensory map. The odorant receptor is expressed at the cilia, where it binds odorants, and at the axon terminal.
Zamparo, Ilaria +12 more
openaire +4 more sources