Results 41 to 50 of about 304,829 (369)
Frontiers in Neuroscience, 2022 Local control of gene expression provides critical mechanisms for regulating development, maintenance and plasticity in the nervous system. Among the strategies known to govern gene expression locally, mRNA transport and translation have emerged as ...
Reed T. Bjork +4 more
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A model of fasciculation and sorting in mixed populations of axons [PDF]
Phys. Rev. E 84, 021908 (2011), 2010 We extend a recently proposed model (Chaudhuri et al., EPL 87, 20003 (2009)) aiming to describe the formation of fascicles of axons during neural development. The growing axons are represented as paths of interacting directed random walkers in two spatial dimensions.
arxiv +1 more source
Understanding axon guidance: are we nearly there yet?
Development, 2018 During nervous system development, neurons extend axons to reach their targets and form functional circuits. The faulty assembly or disintegration of such circuits results in disorders of the nervous system.
E. Stoeckli
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The Axon Initial Segment: An Updated Viewpoint
Journal of Neuroscience, 2018 At the base of axons sits a unique compartment called the axon initial segment (AIS). The AIS generates and shapes the action potential before it is propagated along the axon.
Christophe Leterrier
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Determination of immunogenic proteins in biopharmaceuticals by UHPLC–MS amino acid analysis
BMC Chemistry, 2019 Nowadays, there is a growing interest in innovative and more efficient therapeutics—biopharmaceuticals, based on peptides or proteins. There are increased demands on quality control of such therapeutics.
Juraj Piestansky +4 more
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The Genetics of Axonal Transport and Axonal Transport Disorders
PLoS Genetics, 2006 Neurons are specialized cells with a complex architecture that includes elaborate dendritic branches and a long, narrow axon that extends from the cell body to the synaptic terminal. The organized transport of essential biological materials throughout the neuron is required to support its growth, function, and viability.
Lawrence S.B. Goldstein, Jason E. Duncan
openaire +5 more sources
Nature Communications, 2018 Neurons display extreme degrees of polarization, including compartment-specific organelle morphology. In cortical, long-range projecting, pyramidal neurons (PNs), dendritic mitochondria are long and tubular whereas axonal mitochondria display uniformly ...
Tommy L. Lewis +4 more
semanticscholar +1 more source
Advances in the study of axon–associated vesicles
Frontiers in Molecular Neuroscience, 2022 The central nervous system is the most important and difficult to study system in the human body and is known for its complex functions, components, and mechanisms. Neurons are the basic cellular units realizing neural functions. In neurons, vesicles are
Yanling Liu +6 more
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Axon Membrane Skeleton Structure is Optimized for Coordinated Sodium Propagation [PDF]
PLOS Computational Biology, 13, Issue 2, e1005407, (2017), 2016 Axons transmit action potentials with high fidelity and minimal jitter. This unique capability is likely the result of the spatiotemporal arrangement of sodium channels along the axon. Super-resolution microscopy recently revealed that the axon membrane skeleton is structured as a series of actin rings connected by spectrin filaments that are held ...
arxiv +1 more source
The Axon-Myelin Unit in Development and Degenerative Disease
Frontiers in Neuroscience, 2018 Axons are electrically excitable, cable-like neuronal processes that relay information between neurons within the nervous system and between neurons and peripheral target tissues.
Ruth M. Stassart +3 more
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