Results 41 to 50 of about 438,323 (349)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Carcinogenesis in Ulcerative Colitis: Is Surveillance Worthwhile?

Canadian Journal of Gastroenterology, 1990
Observations that dysplastic epithelium predicts neoplastic change in the coli tic bowel have led to the adoption of surveillance policies in ulcerative colitis patients, usually involving colonoscopy irrespective of symptomatology.
ATR Axon
doaj   +1 more source

AxonDeepSeg: automatic axon and myelin segmentation from microscopy data using convolutional neural networks [PDF]

, 2017
Segmentation of axon and myelin from microscopy images of the nervous system provides useful quantitative information about the tissue microstructure, such as axon density and myelin thickness. This could be used for instance to document cell morphometry
Antonsanti, Pierre-Louis, Cohen-Adad, Julien, Herman, Victor, Perone, Christian Samuel, Wabartha, Maxime, Zaimi, Aldo   +5 more
core   +3 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Reconnecting through dissociation: a 5-month follow-up case study on ketamine-assisted psychotherapy for anorexia nervosa

Journal of Eating Disorders
Introduction Ketamine, an N-methyl-D-aspartate receptor antagonist, has demonstrated rapid antidepressant effects at sub-anesthetic doses, making it a promising candidate for treatment-resistant mood disorders, anxiety, post-traumatic stress disorder ...
Camilla Lindvall Dahlgren, Elisabeth Tverrli, Lowan Han Stewart   +2 more
doaj   +1 more source

The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells

Frontiers in Molecular Neuroscience, 2017
The microtubule (MT)-associated protein Tau is a natively unfolded protein, involved in a number of neurodegenerative disorders, collectively called tauopathies, aggregating in neurofibrillary tangles (NFT). It is an open question how the conversion from
Cristina Di Primio, Valentina Quercioli, Giacomo Siano, Matteo Rovere, Branislav Kovacech, Michal Novak, Antonino Cattaneo   +6 more
doaj   +1 more source

Epitafio per Timocrito caduto contro gli Etoli

Axon, 2023
L’iscrizione metrica, scoperta a Tirreo in Acarnania e trascritta da un abitante del luogo, è risultata immediatamente irreperibile. Il testo narra le gesta eroiche del soldato Timocrito, caduto in uno scontro con gli Etoli; nel distico elegiaco ...
Marucci, Marta
doaj   +1 more source

Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD+ in axon regeneration. [PDF]

, 2018
The mechanisms underlying axon regeneration in mature neurons are relevant to the understanding of normal nervous system maintenance and for developing therapeutic strategies for injury.
Andrusiak, Matthew G, Cherra, Salvatore J, Chisholm, Andrew D, Jin, Yishi, Kim, Kyung Won, Kurup, Naina, Park, Seungmee, Piggott, Christopher A, Tang, Ngang Heok, Wu, Zilu, Zhu, Ming   +10 more
core   +1 more source

KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS [PDF]

, 2017
Neurons in the adult mammalian CNS decrease in intrinsic axon growth capacity during development in concert with changes in Krüppel-like transcription factors (KLFs). KLFs regulate axon growth in CNS neurons including retinal ganglion cells (RGCs). Here,
Apara, Akintomide, Ashouri, Masoumeh, Blackmore, Murray G., Brown, Dale P., Jr., Fernandes, Kimberly A., Galvao, Joana, Goldberg, Jeffrey L., Huang, Abigail, Iwao, Keiichiro, Kunzevitzky, Noelia J., Libby, Richard T., Moore, Darcie L., Nguyen, Tu, Shaw, Peter S., Trillo, Allison, Wang, Yan, Zhang, Ziong   +16 more
core   +2 more sources