Results 51 to 60 of about 434,135 (356)

KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS [PDF]

, 2017
Neurons in the adult mammalian CNS decrease in intrinsic axon growth capacity during development in concert with changes in Krüppel-like transcription factors (KLFs). KLFs regulate axon growth in CNS neurons including retinal ganglion cells (RGCs). Here,
Apara, Akintomide, Ashouri, Masoumeh, Blackmore, Murray G., Brown, Dale P., Jr., Fernandes, Kimberly A., Galvao, Joana, Goldberg, Jeffrey L., Huang, Abigail, Iwao, Keiichiro, Kunzevitzky, Noelia J., Libby, Richard T., Moore, Darcie L., Nguyen, Tu, Shaw, Peter S., Trillo, Allison, Wang, Yan, Zhang, Ziong   +16 more
core   +2 more sources

The Diverse Neuromuscular Spectrum of VPS13A Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective VPS13A disease (chorea‐acanthocytosis) is a rare neurodegenerative disorder caused by biallelic variants in VPS13A, typically presenting with hyperkinetic movement disorders, while neuromuscular signs are often mild. The aim of the project was to investigate the frequency and severity of neuromuscular impairment in VPS13A disease ...
Anne Buchberger, Evamaria Riedel, Marie Hackenberg, Alexander Mensch, Stefanie Beck‐Woedl, Joohyun Park, Tobias B. Haack, Bernhard Haslinger, Jan Kirschke, Holger Prokisch, Andreas Hermann, Christian Mawrin, Adrian Danek, Benedikt Schoser, Kevin Peikert, Marcus Deschauer, Isabell Cordts   +16 more
wiley   +1 more source

Post hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer’s disease, positive for plasma p-tau217

Alzheimer’s Research & Therapy
Background The spread of tau pathology closely correlates with the disease course and cognitive decline in Alzheimer’s disease (AD). Tau-targeting immunotherapies are being developed to stop the spread of tau pathology and thus halt disease progression ...
Branislav Kovacech, Nicholas C. Cullen, Petr Novak, Jozef Hanes, Eva Kontsekova, Stanislav Katina, Vojtech Parrak, Michal Fresser, Jeroen Vanbrabant, Howard H. Feldman, Bengt Winblad, Erik Stoops, Eugeen Vanmechelen, Norbert Zilka   +13 more
doaj   +1 more source

Efficacy assessment of an active tau immunotherapy in Alzheimer’s disease patients with amyloid and tau pathology: a post hoc analysis of the “ADAMANT” randomised, placebo-controlled, double-blind, multi-centre, phase 2 clinical trialResearch in context

EBioMedicine
Summary: Background: Tau pathology correlates with and predicts clinical decline in Alzheimer’s disease. Approved tau-targeted therapies are not available.
Nicholas C. Cullen, Petr Novak, Duygu Tosun, Branislav Kovacech, Jozef Hanes, Eva Kontsekova, Michal Fresser, Stefan Ropele, Howard H. Feldman, Reinhold Schmidt, Bengt Winblad, Norbert Zilka   +11 more
doaj   +1 more source

Inscription from Caria Mentioning Antiochus III, Ptolemy V, and Philip V

Axon, 2023
The ‘Three Kings’ Inscription’ bears the fragment of a Rhodian arbitration between Bargylia and another town in Caria. It is an important document, for it described major political events which affected western Caria on the eve of the Second ...
Rossini, Alessandro
doaj   +1 more source

Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21‐Year Period

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Essential tremor is a highly prevalent movement disorder. Pathological changes observed in essential tremor cerebella center around Purkinje cells and neighboring neuronal populations. Postmortem studies have variably, but not always, shown reduced Purkinje cell counts in essential tremor compared to controls.
Chloë A. Kerridge, Roberto S. Hernandez, Nora C. Hernandez, Phyllis L. Faust, Elan D. Louis   +4 more
wiley   +1 more source

Addressing Climate Change and the Role of Technological Solutions [PDF]

Human Geographies: Journal of Studies and Research in Human Geography, 2010
As far as sustainability is concerned, the role of technology has always been contested. With regard to environmental degradation, technology is either perceived to be part of the problem or part of the solution.
Stephen Axon
doaj  

The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells

Frontiers in Molecular Neuroscience, 2017
The microtubule (MT)-associated protein Tau is a natively unfolded protein, involved in a number of neurodegenerative disorders, collectively called tauopathies, aggregating in neurofibrillary tangles (NFT). It is an open question how the conversion from
Cristina Di Primio, Valentina Quercioli, Giacomo Siano, Matteo Rovere, Branislav Kovacech, Michal Novak, Antonino Cattaneo   +6 more
doaj   +1 more source

Pronunciamento per gli Elei

Axon, 2023
Come le altre, anche la ϝράτρα per gli Elei è un oracolo di Zeus Olimpio; in questo caso, il dio ordina di trattare lo straniero – e segretario – Patrias come fosse un eleo, quando sia vittima di una maledizione.
Zunino, Maddalena Luisa
doaj   +1 more source

The Genetics of Axonal Transport and Axonal Transport Disorders

PLoS Genetics, 2006
Neurons are specialized cells with a complex architecture that includes elaborate dendritic branches and a long, narrow axon that extends from the cell body to the synaptic terminal. The organized transport of essential biological materials throughout the neuron is required to support its growth, function, and viability.
Jason E Duncan, Lawrence S B Goldstein
openaire   +4 more sources