Results 51 to 60 of about 304,829 (369)
Presynaptic contact and activity opposingly regulate postsynaptic dendrite outgrowth
eLife, 2022 The organization of neural circuits determines nervous system function. Variability can arise during neural circuit development (e.g. neurite morphology, axon/dendrite position).
Emily L Heckman, Chris Q Doe
doaj +1 more source
In vivo measurement of afferent activity with axon-specific calcium imaging
Nature Neuroscience, 2018 In vivo calcium imaging from axons provides direct interrogation of afferent neural activity, informing the neural representations that a local circuit receives.
G. Broussard +8 more
semanticscholar +1 more source
EBioMedicine, 2022 Summary: Background: The emergence of new SARS-CoV-2 variants of concern B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma) and B.1.617.2 (Delta) that harbor mutations in the viral S protein raised concern about activity of current vaccines and therapeutic ...
Branislav Kovacech +44 more
doaj
Modeling tau transport in the axon initial segment [PDF]
Mathematical Biosciences, vol. 329, article # 108468, 2020, 2020 By assuming that tau protein can be in seven kinetic states, we developed a model of tau protein transport in the axon and in the axon initial segment (AIS). Two separate sets of kinetic constants were determined, one in the axon and the other in the AIS.
arxiv +1 more source
Intra-axonal mechanisms driving axon regeneration
Brain Research, 2020 Traumatic injury to the peripheral and central nervous systems very often causes axotomy, where an axon loses connections with its target resulting in loss of function. The axon segments distal to the injury site lose connection with the cell body and degenerate.
Terika P. Smith +3 more
openaire +3 more sources
Virtual mouse brain histology from multi-contrast MRI via deep learning
eLife, 2022 1H MRI maps brain structure and function non-invasively through versatile contrasts that exploit inhomogeneity in tissue micro-environments. Inferring histopathological information from magnetic resonance imaging (MRI) findings, however, remains ...
Zifei Liang +9 more
doaj +1 more source
A Fractional Viscoelastic Model Of The Axon In Brain White Matter [PDF]
arXiv, 2023 Traumatic axonal injury occurs when loads experienced on the tissue-scale are transferred to the individual axons. Mechanical characterization of axon deformation especially under dynamic loads however is extremely difficult owing to their viscoelastic properties.
arxiv
Axon initial segments: structure, function, and disease
Annals of the New York Academy of Sciences, 2018 The axon initial segment (AIS) is located at the proximal axon and is the site of action potential initiation. This reflects the high density of ion channels found at the AIS.
C. Huang, M. Rasband
semanticscholar +1 more source
Frontiers in Molecular Neuroscience, 2021 Over four decades ago, in vitro experiments showed that tau protein interacts with and stabilizes microtubules in a phosphorylation-dependent manner. This observation fueled the widespread hypotheses that these properties extend to living neurons and ...
Rebecca L. Mueller +11 more
doaj +1 more source
Graphene promotes axon elongation through local stall of Nerve Growth Factor signaling endosomes [PDF]
, 2020 Several works reported increased differentiation of neuronal cells grown on graphene; however, the molecular mechanism driving axon elongation on this material has remained elusive. Here, we study the axonal transport of nerve growth factor (NGF), the neurotrophin supporting development of peripheral neurons, as a key player in the time course of ...
arxiv +1 more source