Results 91 to 100 of about 6,316,330 (345)
Advanced Functional Materials, EarlyView.A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker +16 more
wiley +1 more source
Mechanisms of Axon Elongation Following CNS Injury: What Is Happening at the Axon Tip?
Frontiers in Cellular Neuroscience, 2020 After an injury to the central nervous system (CNS), functional recovery is limited by the inability of severed axons to regenerate and form functional connections with appropriate target neurons beyond the injury.
William Rodemer +4 more
doaj +1 more source
Role of GPR55 during Axon Growth and Target Innervation
eNeuro, 2015 Guidance molecules regulate the navigation of retinal ganglion cell (RGC) projections toward targets in the visual thalamus. In this study, we demonstrate that the G-protein-coupled receptor 55 (GPR55) is expressed in the retina during development, and ...
Hosni Cherif +8 more
semanticscholar +1 more source
Intra-Axonal Translation of RhoA Promotes Axon Growth Inhibition by CSPG [PDF]
The Journal of Neuroscience, 2012 Chondroitin sulfate proteoglycans (CSPGs) are a major component of the glial scar that contributes to the limited regeneration of the CNS after axonal injury. However, the intracellular mechanisms that mediate the effects of CSPGs are not fully understood.
Breset A, Walker +2 more
openaire +2 more sources
Peptide Sequencing With Single Acid Resolution Using a Sub‐Nanometer Diameter Pore
Advanced Functional Materials, EarlyView.To sequence a single molecule of Aβ1−42–sodium dodecyl sulfate (SDS), the aggregate is forced through a sub‐nanopore 0.4 nm in diameter spanning a 4.0 nm thick membrane. The figure is a visual molecular dynamics (VMD) snapshot depicting the translocation of Aβ1−42–SDS through the pore; only the peptide, the SDS, the Na+ (yellow/green) and Cl− (cyan ...
Apurba Paul +8 more
wiley +1 more source
Retrograde Ret signaling controls sensory pioneer axon outgrowth
eLife, 2019 The trafficking mechanisms and transcriptional targets downstream of long-range neurotrophic factor ligand/receptor signaling that promote axon growth are incompletely understood. Zebrafish carrying a null mutation in a neurotrophic factor receptor, Ret,
Adam Tuttle +4 more
doaj +1 more source
Neural Development, 2015 BackgroundRac1 is a critical regulator of cytoskeletal dynamics in multiple cell types. In the nervous system, it has been implicated in the control of cell proliferation, neuronal migration, and axon development.ResultsTo systematically investigate the ...
Zhong L. Hua +2 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang +9 more
wiley +1 more source
A neural network growing algorithm based on Brownian movement and gravity constraint
Advances in Mechanical Engineering, 2018 A growing algorithm of neural network based on axon growth is developed in this article. At the beginning, the Newtonian gravitation and the Brownian motion are employed to establish an axon growth model, and the constraint function of the neural axon ...
Ming Liu +5 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2017 Limited axon regeneration in the injured adult mammalian central nervous system (CNS) usually results in irreversible functional deficits. Both the presence of extrinsic inhibitory molecules at the injury site and the intrinsically low capacity of adult ...
Vinicius T. Ribas, Marcos R. Costa
doaj +1 more source