Results 91 to 100 of about 6,093,797 (222)
Modelling axon growing using CTRW [PDF]
arXiv, 2015 The main goal of this study is to propose a mathematical model describing paths of the axon growth cones and differences in the behavior of normal and mutant axons. We introduce a probabilistic model for axon growing, such that each family of axons is described as an ensemble of trajectories of a continuous time random walk (CTRW) model under different
arxiv
Human Molecular Genetics, 2015 Abnormal axonal connectivity and hyperactive mTOR complex 1 (mTORC1) are shared features of several neurological disorders. Hyperactive mTORC1 alters axon length and polarity of hippocampal neurons in vitro, but the impact of hyperactive mTORC1 on axon ...
Xuan Gong +7 more
semanticscholar +1 more source
Event-Triggered Control of Neuron Growth with Actuation at Soma [PDF]
arXiv, 2023 We introduce a dynamic event-triggering mechanism for regulating the axonal growth of a neuron. We apply boundary actuation at the soma (the part of a neuron that contains the nucleus) and regulate the dynamics of tubulin concentration and axon length.
arxiv
Axon growth inhibition by RhoA/ROCK in the central nervous system
Frontiers in Neuroscience, 2014 Rho kinase (ROCK) is a serine/threonine kinase and a downstream target of the small GTPase Rho. The RhoA/ROCK pathway is associated with various neuronal functions such as migration, dendrite development, and axonal extension.
Y. Fujita, T. Yamashita
semanticscholar +1 more source
Scientific Reports, 2019 The process of mitochondrial fission-fusion has been implicated in diverse neuronal roles including neuronal survival, axon degeneration, and axon regeneration.
Alexander Kreymerman +13 more
doaj +1 more source
Neuronal Growth as Diffusion in an Effective Potential [PDF]
, 2013 Current understanding of neuronal growth is mostly qualitative, as the staggering number of physical and chemical guidance cues involved prohibit a fully quantitative description of axonal dynamics. We report on a general approach that describes axonal growth in vitro, on poly-D-lysine coated glass substrates, as diffusion in an effective external ...
arxiv +1 more source
DSCAM promotes axon fasciculation and growth in the developing optic pathway
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Our findings demonstrate a function for Down syndrome cell adhesion molecule (DSCAM) in the embryonic development of the mouse visual system.
Freyja Bruce +4 more
semanticscholar +1 more source
Neural Development, 2008 Background Cell adhesion molecules have long been implicated in the regulation of axon growth, but the precise cellular roles played by individual cell adhesion molecules and the molecular basis for their action are still not well understood.
Martin Veronica +5 more
doaj +1 more source
Journal of Experimental Medicine, 2014 Intraneuronal activation of B-RAF kinase is sufficient to drive the growth of peripheral axon projections and enables robust regenerative axon growth in the injured optic nerve.
K. O’Donovan +12 more
semanticscholar +1 more source
eLife, 2019 Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in C.
Yue Qu +11 more
doaj +1 more source