Results 1 to 10 of about 933,512 (199)
RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury
Neuron, 2021 An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from regenerating in the adult central nervous system (CNS). Here we show how the two aspects are interwoven.
Brett J Hilton +2 more
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Cell Metabolism, 2020 Summary Axons in the mature central nervous system (CNS) fail to regenerate after axotomy, partly due to the inhibitory environment constituted by reactive glial cells producing astrocytic scars, chondroitin sulfate proteoglycans and myelin debris.
Harun N Noristani +2 more
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The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration
Neuron, 2019 SUMMARY Neurons exhibit a limited ability of repair. Given that mechanical forces affect neuronal outgrowth, it is important to investigate whether mechanosensitive ion channels may regulate axon regeneration. Here, we show that DmPiezo, a Ca2+-permeable
Yuanquan Song +2 more
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Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH
Autophagy, 2020 Macroautophagy/autophagy is essential for maintaining cellular homeostasis through the degradation of organelles and proteins. It also has a prominent role in modulating aging.
Su Hyuk Ko, Ellen C Apple, Zhijie Liu
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Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells
Neuron, 2019 Summary Neuronal subtypes show diverse injury responses, but the molecular underpinnings remain elusive. Using transgenic mice that allow reliable visualization of axonal fate, we demonstrate that intrinsically photosensitive-retinal ganglion cells ...
Eric R Bray +2 more
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Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System
Neuron, 2018 SUMMARY N6-methyladenosine (m6A) affects multiple aspects of mRNA metabolism and regulates developmental transitions by promoting mRNA decay. Little is known about the role of m6A in the adult mammalian nervous system.
Yi-Lan Weng +2 more
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Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration
Cell Reports, 2018 Summary: RNA-binding proteins Lin28a/b regulate cellular growth and tissue regeneration. Here, we investigated the role of Lin28 in the control of axon regeneration in postmitotic neurons.
Xue-Wei Wang +9 more
doaj +2 more sources
ADF/Cofilin-Mediated Actin Turnover Promotes Axon Regeneration in the Adult CNS
Neuron, 2019 SUMMARY Injured axons fail to regenerate in the adult central nervous system, which contrasts their vigorous growth during embryonic development. We explored the potential of re-initiating axon extension after injury by reactivating the molecular ...
Andrea Tedeschi +2 more
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Interplay of axon regeneration genes and immune infiltration in spinal cord injury [PDF]
Journal of Translational MedicineBackground Spinal Cord Injury (SCI) impacts neural function and regeneration. This study aimed to identify key axon regeneration genes in SCI and their correlations with immune infiltration and SCI subtyping.
Zimin Xiang +9 more
doaj +2 more sources
Increased ER–mitochondria tethering promotes axon regeneration
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Small organelles such as endoplasmic reticulum (ER) and mitochondria play key roles in cellular functions and survival. Furthermore, physical tethering between ER–mitochondria allows communication between these 2 organelles, and proteins ...
Soyeon Lee, Kyung-Tai Min
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