Results 11 to 20 of about 938,041 (332)

Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration [PDF]

Nature Communications
Motor axon regeneration following peripheral nerve injury is critical for motor recovery but therapeutic interventions enhancing this are not available.
Keunjung Heo, Tammy Szu-Yu Ho, Xiangsunze Zeng, Bruna Lenfers Turnes, Maryam Arab, Selwyn Jayakar, Kuchuan Chen, Georgios Kimourtzis, Michael C. Condro, Elisa Fazzari, Xuan Song, J. Tabitha Hees, Zhuqiu Xu, Xirui Chen, Lee B. Barrett, Laura Perrault, Roshan Pandey, Kathleen Zhang, Aparna Bhaduri, Zhigang He, Harley I. Kornblum, Jed Hubbs, Clifford J. Woolf   +22 more
doaj   +3 more sources

Interleukin-4 protects retinal ganglion cells and promotes axon regeneration [PDF]

Cell Communication and Signaling
Background The preservation of retinal ganglion cells (RGCs) and the facilitation of axon regeneration are crucial considerations in the management of various vision-threatening disorders. Therefore, we investigate the efficacy of interleukin-4 (IL-4), a
Zhaoyang Zuo, Bin Fan, Ziyuan Zhang, Yang Liang, Jing Chi, Guangyu Li   +5 more
doaj   +3 more sources

Axon regeneration in C. elegans [PDF]

Current Opinion in Neurobiology, 2014
Single axon transection by laser surgery has made Caenorhabditis elegans a new model for axon regeneration. Multiple conserved molecular signaling modules have been discovered through powerful genetic screening. In vivo imaging with single cell and axon resolution has revealed unprecedented cellular dynamics in regenerating axons.
Hammarlund, Marc, Jin, Yishi
core   +7 more sources

Normal Spastin Gene Dosage Is Specifically Required for Axon Regeneration

Cell Reports, 2012
Axon regeneration allows neurons to repair circuits after trauma; however, most of the molecular players in this process remain to be identified. Given that microtubule rearrangements have been observed in injured neurons, we tested whether microtubule ...
Michelle C. Stone, Kavitha Rao, Kyle W. Gheres, Seahee Kim, Juan Tao, Caroline La Rochelle, Christin T. Folker, Nina T. Sherwood, Melissa M. Rolls   +8 more
doaj   +2 more sources

Fcγ receptor-mediated inflammation inhibits axon regeneration. [PDF]

PLoS ONE, 2014
Anti-glycan/ganglioside antibodies are the most common immune effectors found in patients with Guillain-Barré Syndrome, which is a peripheral autoimmune neuropathy.
Gang Zhang, Nataliia Bogdanova, Tong Gao, Julia J Song, Mark S Cragg, Martin J Glennie, Kazim A Sheikh   +6 more
doaj   +2 more sources

Integrin Activation: Implications for Axon Regeneration [PDF]

Cells, 2018
Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by ‘inside–out’ and ‘outside–in’ signalling.
Menghon Cheah, Melissa Andrews
openaire   +8 more sources

Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration

Neuron, 2019
Summary How adult neurons coordinate lipid metabolism to regenerate axons remains elusive. We found that depleting neuronal lipin1, a key enzyme controlling the balanced synthesis of glycerolipids through the glycerol phosphate pathway, enhanced axon ...
Chao Yang, Xu Wang, Jianying Wang, Xuejie Wang, Weitao Chen, Na Lu, S. Siniossoglou, Z. Yao, Kai Liu   +8 more
semanticscholar   +3 more sources

Inhibition of Axon Regeneration by Liquid-like TIAR-2 Granules

Neuron, 2019
Summary Phase separation into liquid-like compartments is an emerging property of proteins containing prion-like domains (PrLDs), yet the in vivo roles of phase separation remain poorly understood. TIA proteins contain a C-terminal PrLD, and mutations in
Zhiping Wang, Andrea M Dickey, Zilu Wu
exaly   +2 more sources

Axon regeneration in C. elegans: Worming our way to mechanisms of axon regeneration [PDF]

Experimental Neurology, 2017
How axons repair themselves after injury is a fundamental question in neurobiology. With its conserved genome, relatively simple nervous system, and transparent body, C. elegans has recently emerged as a productive model to uncover the cellular mechanisms that regulate and execute axon regeneration.
Alexandra B Byrne, Marc Hammarlund
exaly   +3 more sources

Cytoskeleton dynamics in axon regeneration

Current Opinion in Neurobiology, 2018
Recent years have seen cytoskeleton dynamics emerging as a key player in axon regeneration. The cytoskeleton, in particular microtubules and actin, ensures the growth of neuronal processes and maintains the singular, highly polarized shape of neurons. Following injury, adult central axons are tipped by a dystrophic structure, the retraction bulb, which
Blanquie, Oriane, Bradke, Frank
openaire   +4 more sources