Results 31 to 40 of about 938,041 (332)
An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury
Neuron, 2021 Summary Axons in the adult mammalian central nervous system fail to regenerate after spinal cord injury. Neurons lose their capacity to regenerate during development, but the intracellular processes underlying this loss are unclear.
Brett J. Hilton +12 more
semanticscholar +1 more source
Frontiers in Molecular Neuroscience, 2022 Injured sensory neurons activate a transcriptional program necessary for robust axon regeneration and eventual target reinnervation. Understanding the transcriptional regulators that govern this axon regenerative response may guide therapeutic strategies
Oshri Avraham +9 more
doaj +1 more source
Cell Reports, 2020 Summary: In addition to altered gene expression, pathological cytoskeletal dynamics in the axon are another key intrinsic barrier for axon regeneration in the central nervous system (CNS). Here, we show that knocking out myosin IIA and IIB (myosin IIA/B)
Xue-Wei Wang +12 more
doaj +1 more source
Cells, 2021 CNS neurons are generally incapable of regenerating their axons after injury due to several intrinsic and extrinsic factors, including the presence of axon growth inhibitory molecules. One such potent inhibitor of CNS axon regeneration is Reticulon (RTN)
Sharif Alhajlah +2 more
doaj +1 more source
PDK1 is a negative regulator of axon regeneration
Molecular Brain, 2021 Axon regeneration in the central nervous system is inefficient. However, the neurons in the peripheral nervous system display robust regeneration after injury, indicating that axonal regeneration is differentially controlled under various conditions.
Hyemin Kim, Jinyoung Lee, Yongcheol Cho
doaj +1 more source
A novel neutrophil subset promotes CNS neuron survival and axon regeneration
Nature Immunology, 2020 Transected axons typically fail to regenerate in the central nervous system (CNS), resulting in chronic neurological disability in individuals with traumatic brain or spinal cord injury, glaucoma and ischemia–reperfusion injury of the eye.
A. Sas +7 more
semanticscholar +1 more source
Migrating Schwann cells direct axon regeneration within the peripheral nerve bridge
Glia, 2020 Schwann cells within the peripheral nervous system possess a remarkable regenerative potential. Current research shows that peripheral nerve‐associated Schwann cells possess the capacity to promote repair of multiple tissues including peripheral nerve ...
Qing Min, D. Parkinson, Xin-peng Dun
semanticscholar +1 more source
eLife, 2016 Axons fail to regenerate after central nervous system (CNS) injury. Modulation of the PTEN/mTORC1 pathway in retinal ganglion cells (RGCs) promotes axon regeneration after optic nerve injury.
Xinzheng Guo, William D Snider, Bo Chen
doaj +1 more source
Neuronal deletion of GSK3beta increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2 [PDF]
, 2014 BackgroundIn the adult central nervous system, axonal regeneration is abortive. Regulators of microtubule dynamics have emerged as attractive targets to promote axonal growth following injury as microtubule organization is pivotal for growth cone ...
Sílvia Vieira +25 more
core +1 more source
Inhibiting poly(ADP-ribosylation) improves axon regeneration
eLife, 2016 The ability of a neuron to regenerate its axon after injury depends in part on its intrinsic regenerative potential. Here, we identify novel intrinsic regulators of axon regeneration: poly(ADP-ribose) glycohodrolases (PARGs) and poly(ADP-ribose ...
Alexandra B Byrne +5 more
doaj +1 more source