Results 21 to 30 of about 938,041 (332)
An Intrinsic Epigenetic Barrier for Functional Axon Regeneration
Neuron, 2017 SUMMARY Mature neurons in the adult peripheral nervous system can effectively switch from a dormant state with little axonal growth to robust axon regeneration upon injury.
Yi-Lan Weng, Ruifa Mi, Chun Zhong
exaly +2 more sources
Aberrant information transfer interferes with functional axon regeneration
eLife, 2018 Functional axon regeneration requires regenerating neurons to restore appropriate synaptic connectivity and circuit function. To model this process, we developed an assay in Caenorhabditis elegans that links axon and synapse regeneration of a single ...
Chen Ding, Marc Hammarlund
doaj +2 more sources
Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway [PDF]
Molecular NeurodegenerationBackground Axon regeneration within the mammalian central nervous system is extremely limited. In optic neuropathy conditions like glaucoma, the inability of retinal ganglion cell (RGC) axons to regenerate is a major impediment to functional recovery. In
Mengming Hu, Matthew B. Veldman
doaj +2 more sources
Axonal Regeneration by Glycosaminoglycan [PDF]
Frontiers in Cell and Developmental Biology, 2021 Like other biomolecules including nucleic acid and protein, glycan plays pivotal roles in various cellular processes. For instance, it modulates protein folding and stability, organizes extracellular matrix and tissue elasticity, and regulates membrane trafficking.
Kazuma Sakamoto +4 more
openaire +3 more sources
A redox-dependent switch governing sensory axon degeneration and regeneration
Scientific ReportsZebrafish (Danio rerio) fin amputation is a widely used model for studying sensory axon degeneration and regeneration. After injury, sensory neuron terminals rapidly degenerate before regenerating.
Chia-Jung Hsieh +2 more
doaj +2 more sources
Thymosin β4 promotes zebrafish Mauthner axon regeneration by facilitating actin polymerization through binding to G-actin [PDF]
BMC BiologyBackground Thymosin beta 4 (Tβ4) is a monomeric actin-binding protein that plays many roles in biological activities. However, some studies on the role of Tβ4 in central axon regeneration have yielded contradictory results.
Zheng Song, Along Han, Bing Hu
doaj +2 more sources
Pharmaceutical Biology, 2023 Context Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of safflower (Carthamus tinctorius L., [Asteraceae]) for traumatic brain injury (TBI) treatment.
En Hu +9 more
semanticscholar +1 more source
Frontiers in Immunology, 2022 Traumatic optic neuropathy (TON) refers to a pathological condition caused by a direct or indirect insult to the optic nerves, which often leads to a partial or permanent vision deficit due to the massive loss of retinal ganglion cells (RGCs) and their ...
N. Au, C. Ma
semanticscholar +1 more source
EFA6 in Axon Regeneration, as a Microtubule Regulator and as a Guanine Nucleotide Exchange Factor
Cells, 2021 Axon regeneration after injury is a conserved biological process that involves a large number of molecular pathways, including rapid calcium influx at injury sites, retrograde injury signaling, epigenetic transition, transcriptional reprogramming ...
Gilberto Gonzalez, Lizhen Chen
doaj +1 more source
Neuron, 2022 SUMMARY The coordination mechanism of neural innate immune responses for axon regeneration is not well understood. Here, we showed that neuronal deletion of protein tyrosine phosphatase non-receptor type 2 sustains the IFNγ-STAT1 activity in retinal ...
Xu Wang +17 more
semanticscholar +1 more source