Results 41 to 50 of about 938,041 (332)
GAP-43 and BASP1 in Axon Regeneration: Implications for the Treatment of Neurodegenerative Diseases
Frontiers in Cell and Developmental Biology, 2020 Growth-associated protein-43 (GAP-43) and brain acid-soluble protein 1 (BASP1) regulate actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal growth, regeneration, and plasticity.
Daayun Chung, Andrew K. Shum, G. Caraveo
semanticscholar +1 more source
Astrocyte scar formation aids CNS axon regeneration
Nature, 2016 Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are widely regarded as causal in this failure. Here, using three genetically targeted loss-of-function manipulations in adult mice, we show that preventing astrocyte ...
Mark A. Anderson +9 more
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Commissural Axon Kinetics and the Role of Netrin in Early Brain Circuitry Development [PDF]
, 2005 As neurons begin to differentiate, they send out processes called axons to initiate the formation of functional nerve connections. A specialized structure at the end of an axon called the growth cone is believed to possess the impressive navigational and
Bak-Maier, Magdalena
core +1 more source
Frontiers in Bioengineering and Biotechnology, 2020 Strategies to accelerate the rate of axon regeneration would improve functional recovery following peripheral nerve injury, in particular for cases involving segmental nerve defects.
Kritika S. Katiyar +23 more
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Guidance Molecules in Axon Regeneration [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 The regenerative capacity of injured adult mammalian central nervous system (CNS) tissue is very limited. Disease or injury that causes destruction or damage to neuronal networks typically results in permanent neurological deficits. Injury to the spinal cord, for example, interrupts vital ascending and descending fiber tracts of spinally projecting ...
Roman J, Giger +2 more
openaire +2 more sources
Cell Metabolism, 2020 SUMMARY Axonal regeneration in the central nervous system (CNS) is a highly energy demanding process. Extrinsic insults and intrinsic restrictions lead to an energy crisis in injured axons, raising the question of whether recovering energy deficits ...
Qi Han +9 more
semanticscholar +1 more source
, 2022 Injuries to the central nervous system (CNS) such as stroke, brain, and spinal cord trauma often result in permanent disabilities because adult CNS neurons only exhibit limited axon regeneration.
Chow, Shing Fung +9 more
core +1 more source
Frontiers in Molecular Neuroscience, 2017 Axon regeneration, fundamental to nerve repair, and functional recovery, relies on rapid changes in gene expression attributable to microRNA (miRNA) regulation.
Rongchen Huang +5 more
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Wolfram syndrome 1b mutation suppresses Mauthner-cell axon regeneration via ER stress signal pathway
Acta Neuropathologica Communications, 2022 Wolfram Syndrome (WS) is a fatal human inherited disease with symptoms of diabetes, vision decreasing, and neurodegeneration caused by mutations in the endoplasmic reticulum (ER)-resident protein WFS1.
Zongyi Wang +4 more
doaj +1 more source
Bioactive Materials, 2023 Chitosan and its degradation product, oligosaccharides, have been shown to facilitate peripheral nerve regeneration. However, the underlying mechanisms are not well understood.
Yahong Zhao +8 more
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