Results 61 to 70 of about 938,041 (332)
Regeneration of corticospinal axons in the rat [PDF]
Annals of Neurology, 1977 AbstractIn the rat, a few long descending motor tracts capable of carrying an impulse and causing a propagated impulse in the ipsilateral sciatic nerve will regenerate after complete spinal cord transection. In this experiment such regeneration was found in both treated and control animals.Orthograde axonal transport of tritiated proline injected into ...
Feringa, Earl R. +3 more
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Molecular Therapy: Nucleic Acids, 2020 Irreversible blindness from glaucoma and optic neuropathies is attributed to retinal ganglion cells (RGCs) losing the ability to regenerate axons. While several transcription factors and proteins have demonstrated enhancement of axon regeneration after ...
Heather K. Mak +12 more
doaj +1 more source
Neural Regeneration Research, 2019 Membrane trafficking processes are presumably vital for axonal regeneration after injury, but mechanistic understanding in this regard has been sparse. A recent loss-of-function screen had been carried out for factors important for axonal regeneration by cultured cortical neurons and the results suggested that the activity of a number of Rab GTPases ...
Cheryl Qian Ying Yong, Bor Luen Tang
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Gliotransmission and adenosine signaling promote axon regeneration
, 2023 How glia control axon regeneration remains incompletely understood. Here, we investigate glial regulation of regenerative ability differences of closely related Drosophila larval sensory neuron subtypes.
Ruppell, Kendra Takle +10 more
core +1 more source
F1000Research, 2016 The capacity of an axon to regenerate is regulated by its external environment and by cell-intrinsic factors. Studies in a variety of organisms suggest that alterations in axonal microtubule (MT) dynamics have potent effects on axon regeneration.
Ngang Heok Tang, Andrew D. Chisholm
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PLoS Genetics, 2023 Axon regeneration requires actomyosin interaction, which generates contractile force and pulls the regenerating axon forward. In Caenorhabditis elegans, TLN-1/talin promotes axon regeneration through multiple down-stream events.
Yoshiki Sakai +4 more
doaj +1 more source
BMP signaling in axon regeneration [PDF]
Current Opinion in Neurobiology, 2014 Neuronal competence to re-extend axons and a permissive environment that allows growth cone navigation are two major determinants for successful axon regeneration. Here, we review the roles of bone morphogenetic protein (BMP) signaling in mediating both neuronal and glial injury responses after CNS injury.
Jian, Zhong, Hongyan, Zou
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Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs
Neuron, 2019 SUMMARY Despite robust effects on immature neurons, growth factors minimally promote axon regeneration in the adult central nervous system (CNS). Attempting to improve growth factor responsiveness in mature neurons by dedifferentiation, we over-expressed
Yiling Zhang +8 more
semanticscholar +1 more source
MicroRNA-9 regulates mammalian axon regeneration in peripheral nerve injury
Molecular Pain, 2017 Effective axon regeneration is achieved mainly by precise regulation of gene expression after peripheral nerve injury. MicroRNAs play an important role in controlling axon regeneration owe to its key epigenetic function in regulating gene expression ...
Jingjing Jiang +6 more
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Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance This work presents a concept for promoting the neuronal regenerative potential by engineering the expression of a stem cell marker, Prom1. We identify Prom1 as a developmentally down-regulated neuronal intrinsic factor of axon regeneration ...
Jinyoung Lee +7 more
semanticscholar +1 more source