Results 71 to 80 of about 938,041 (332)

Intrinsic mechanisms of neuronal axon regeneration

Nature Reviews Neuroscience, 2018
Permanent disabilities following CNS injuries result from the failure of injured axons to regenerate and rebuild functional connections with their original targets.
Marcus Mahar, V. Cavalli
semanticscholar   +1 more source

Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons

, 2014
This work was supported by the Medical Research Council, the Christopher and Dana Reeve Foundation, the John and Lucille van Geest Foundation, the Henry Smith Charity, the Commonwealth and Overseas scholarships, and the Hinduja Cambridge Trust.PNS axons ...
Cheah, Menghon, Dotti, Carlos G, Andrews, Melissa R., Andrews, Melissa Renee, Kappagantula, Sunil, Abad-Rodriguez, Jose', Abad-Rodriguez, José, Fawcett, James W   +7 more
core   +1 more source

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system

eLife, 2016
Injured mature CNS axons do not regenerate in mammals. Deletion of PTEN, the negative regulator of PI3K, induces CNS axon regeneration through the activation of PI3K-mTOR signaling.
Linqing Miao, Liu Yang, Haoliang Huang, Feisi Liang, Chen Ling, Yang Hu   +5 more
doaj   +1 more source

Models of axon regeneration in Drosophila [PDF]

Experimental Neurology, 2017
Maintaining neuronal connectivity in the face of injury and disease is a major challenge for the nervous system. The great length of axons makes them particularly vulnerable to insult with dire consequences for neuronal function. In the peripheral nervous system there is a program of axonal regeneration that can reestablish connectivity.
E.J. Brace, Aaron DiAntonio
openaire   +2 more sources

PI 3‐kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

EMBO Molecular Medicine, 2020
Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons lose regenerative ability after development.
Bart Nieuwenhuis, Amanda C Barber, Rachel S Evans, Craig S Pearson, Joachim Fuchs, Amy R MacQueen, Susan van Erp, Barbara Haenzi, Lianne A Hulshof, Andrew Osborne, Raquel Conceicao, Tasneem Z Khatib, Sarita S Deshpande, Joshua Cave, Charles Ffrench‐Constant, Patrice D Smith, Klaus Okkenhaug, Britta J Eickholt, Keith R Martin, James W Fawcett, Richard Eva   +20 more
doaj   +1 more source

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment after spinal cord injury in rodents

Science Translational Medicine, 2019
Environmental enrichment induces activity-dependent histone acetylation via a druggable mechanism to promote recovery after spinal cord injury. An epigenetic mechanism for regenerating axons Functional recovery after spinal cord injury (SCI) is limited ...
T. Hutson, C. Kathe, I. Palmisano, K. Bartholdi, A. Hervera, Francesco De Virgiliis, E. Mclachlan, Luming Zhou, G. Kong, Q. Barraud, M. Danzi, A. Medrano-Fernández, J. López-Atalaya, A. Boutillier, S. Sinha, A. K. Singh, P. Chaturbedy, L. Moon, T. Kundu, J. Bixby, V. Lemmon, A. Barco, G. Courtine, S. Di Giovanni   +23 more
semanticscholar   +1 more source

Updates and challenges of axon regeneration in the mammalian central nervous system

Journal of Molecular Cell Biology, 2020
Axon regeneration in the mammalian central nervous system (CNS) has been a long-standing and highly challenging issue. Successful CNS axon regeneration will benefit many human diseases involving axonal damage, such as spinal cord injury, traumatic brain ...
Cheng Qian, Feng-Quan Zhou
semanticscholar   +1 more source

c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration.

, 2012
The radical response of peripheral nerves to injury (Wallerian degeneration) is the cornerstone of nerve repair. We show that activation of the transcription factor c-Jun in Schwann cells is a global regulator of Wallerian degeneration.
Jenkins, Billy, Turmaine, Mark, Mirsky, Rhona, Quintes, Susanne, Wicher, GK, Wilton, Daniel K., Chabrol, Elodie, Latouche, Morwena, Chabrol, E, Banerjee, Ambily, Behrens, A, Mirsky, R, Woodhoo, Ashwin, Jenkins, B, Mitter, Richard, Quintes, S, Turmaine, M, Greensmith, L, Jessen, Kristján R., Wicher, Grzegorz K., Woodhoo, A, Mitter, R, Behrens, Axel, Raivich, Gennadij, Wicher, Grzegorz K.,, Latouche, M, Banerjee, Annbily, Arthur-Farraj, PJ, Wilton, DK, Banerjee, A, Rahman, Mary, Jessen, KR, Rahman, M, Arthur-Farraj, Peter J., Greensmith, Linda, Raivich, G   +35 more
core   +1 more source

Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5

eLife, 2023
A key limiting factor of successful axon regeneration is the intrinsic regenerative ability in both the peripheral nervous system (PNS) and central nervous system (CNS).
Dong Wang, Tiemei Zheng, Songlin Zhou, Mingwen Liu, Yaobo Liu, Xiaosong Gu, Susu Mao, Bin Yu   +7 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source