Results 51 to 60 of about 938,041 (332)
Mitochondrial Behavior in Axon Degeneration and Regeneration
Frontiers in Aging Neuroscience, 2021 Mitochondria are organelles responsible for bioenergetic metabolism, calcium homeostasis, and signal transmission essential for neurons due to their high energy consumption. Accumulating evidence has demonstrated that mitochondria play a key role in axon
Biyao Wang +5 more
semanticscholar +1 more source
TIR-1/SARM1 Inhibits Axon Regeneration
, 2021 The inability to repair axonal damage is a feature of neurological impairment after injury and in neurodegenerative diseases. Axonal repair after injury depends in part on intrinsic factors. Several genes cell-autonomously regulate both axon regeneration
Julian, Victoria L.
core +1 more source
Coordination of Necessary and Permissive Signals by PTEN Inhibition for CNS Axon Regeneration
Frontiers in Neuroscience, 2018 In the nearly 10 years since PTEN was identified as a prominent intrinsic inhibitor of CNS axon regeneration, the PTEN negatively regulated PI3K-AKT-mTOR pathway has been intensively explored in diverse models of axon injury and diseases and its ...
Jie Zhang +5 more
doaj +1 more source
rab-27 acts in an intestinal pathway to inhibit axon regeneration in C. elegans.
PLoS Genetics, 2021 Injured axons must regenerate to restore nervous system function, and regeneration is regulated in part by external factors from non-neuronal tissues.
Alexander T Lin-Moore +2 more
doaj +1 more source
Intra-axonal mechanisms driving axon regeneration
Brain Research, 2020 Traumatic injury to the peripheral and central nervous systems very often causes axotomy, where an axon loses connections with its target resulting in loss of function. The axon segments distal to the injury site lose connection with the cell body and degenerate.
Terika P, Smith +3 more
openaire +3 more sources
Synaptic Suppression of Axon Regeneration [PDF]
Neuron, 2016 In this issue of Neuron, Tedeschi et al. (2016) describe the voltage-gated calcium channel subunit alpha2delta2 as a developmental switch from axon elongation to synapse formation and transmission that doubles as a suppressor of axon regeneration, providing a molecular clue for the synaptic stabilization hypothesis of CNS regeneration failure.
Jessica M, Meves, Binhai, Zheng
openaire +2 more sources
Developmental Cell, 2020 In mammals, perivascular cell-derived scarring after spinal cord injury impedes axonal regrowth. In contrast, the extracellular matrix (ECM) in the spinal lesion site of zebrafish is permissive and required for axon regeneration.
Vasiliki Tsata +14 more
semanticscholar +1 more source
, 2021 Source data for "TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron-autonomous ...
Takeshi Nakamura
core +2 more sources
iScience, 2023 Summary: Spinal motor neurons, the distinctive neurons of the central nervous system, extend into the peripheral nervous system and have outstanding ability of axon regeneration after injury.
Ye Zhu +11 more
doaj +1 more source
Axonal regeneration in zebrafish
Current Opinion in Neurobiology, 2014 In contrast to mammals, fish and amphibia functionally regenerate axons in the central nervous system (CNS). The strengths of the zebrafish model, that is, transgenics and mutant availability, ease of gene expression analysis and manipulation and optical transparency of larvae lend themselves to the analysis of successful axonal regeneration.
Becker, Thomas, Becker, Catherina G
openaire +3 more sources