A one-dimensional moving-boundary model for tubulin-driven axonal growth [PDF]
Journal of Theoretical Biology, 358, 2014, 194-207, 2015 A one-dimensional continuum-mechanical model of axonal elongation due to assembly of tubulin dimers in the growth cone is presented. The conservation of mass leads to a coupled system of three differential equations. A partial differential equation models the dynamic and spatial behaviour of the concentration of tubulin that is transported along the ...
arxiv +1 more source
Required growth facilitators propel axon regeneration across complete spinal cord injury
Nature, 2018 Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon growth during development or after injury1–3, but efficient reversal of this regrowth failure ...
Mark A. Anderson +17 more
semanticscholar +1 more source
Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF/β-catenin signaling
Frontiers in Cellular Neuroscience, 2013 Axon morphogenesis is a complex process regulated by a variety of secreted molecules, including morphogens and growth factors, resulting in the establishment of the neuronal circuitry. Our previous work demonstrated that growth factors (Neurotrophins (NT)
Deepshikha eBhardwaj +7 more
doaj +1 more source
Real time large scale $\textit{in vivo}$ observations by light-sheet microscopy reveal intrinsic synchrony, plasticity and growth cone dynamics of midline crossing axons at the ventral floor plate of the zebrafish spinal cord [PDF]
arXiv, 2021 Axonal growth and guidance at the ventral floor plate is here followed $\textit{in vivo}$ in real time at high resolution by light-sheet microscopy along several hundred micrometers of the zebrafish spinal cord. The recordings show the strikingly stereotyped spatio-temporal control that governs midline crossing.
arxiv
Neuronal Alignment On Asymmetric Textured Surfaces [PDF]
Appl. Phys. Lett. 101, 143701 (2012), 2013 Axonal growth and the formation of synaptic connections are key steps in the development of the nervous system. Here we present experimental and theoretical results on axonal growth and interconnectivity in order to elucidate some of the basic rules that neuronal cells use for functional connections with one another.
arxiv +1 more source
Axon growth regulation by a bistable molecular switch
Proceedings of the Royal Society B: Biological Sciences, 2018 For the brain to function properly, its neurons must make the right connections during neural development. A key aspect of this process is the tight regulation of axon growth as axons navigate towards their targets.
P. Padmanabhan, G. Goodhill
semanticscholar +1 more source
Neuronal Growth and Formation of Neuron Networks on Directional Surfaces [PDF]
Biomimetics 6(2), 41 (2021), 2022 The formation of neuron networks is a process of fundamental importance for understanding the development of the nervous system and for creating biomimetic devices for tissue engineering and neural repair. The basic process that controls the network formation is the growth of an axon from the cell body and its extension towards target neurons.
arxiv
Input Delay Compensation for Neuron Growth by PDE Backstepping [PDF]
arXiv, 2022 Neurological studies show that injured neurons can regain their functionality with therapeutics such as Chondroitinase ABC (ChABC). These therapeutics promote axon elongation by manipulating the injured neuron and its intercellular space to modify tubulin protein concentration.
arxiv
Role of geometrical cues in neuronal growth [PDF]
Physical Review E, 99, 022408 (2019), 2019 Geometrical cues play an essential role in neuronal growth. Here, we quantify axonal growth on surfaces with controlled geometries and report a general stochastic approach that quantitatively describes the motion of growth cones. We show that axons display a strong directional alignment on micro-patterned surfaces when the periodicity of the patterns ...
arxiv +1 more source
The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling
Cerebral Cortex, 2017 KIAA0319 is a transmembrane protein associated with dyslexia with a presumed role in neuronal migration. Here we show that KIAA0319 expression is not restricted to the brain but also occurs in sensory and spinal cord neurons, increasing from early ...
F. Franquinho +9 more
semanticscholar +1 more source