Results 81 to 90 of about 6,093,797 (222)
Advanced Functional Materials, EarlyView.This study introduces a conductive nerve guidance conduit integrated with wireless electrical stimulation through alternating magnetic fields, which induces currents and creates a supportive microenvironment for nerve regeneration. In vivo studies show that this approach significantly enhanced myelin restoration, gastrocnemius muscle regeneration ...
Shiheng Liu +7 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2017 Limited axon regeneration in the injured adult mammalian central nervous system (CNS) usually results in irreversible functional deficits. Both the presence of extrinsic inhibitory molecules at the injury site and the intrinsically low capacity of adult ...
Vinicius T. Ribas, Marcos R. Costa
doaj +1 more source
Role of GPR55 during Axon Growth and Target Innervation
eNeuro, 2015 Guidance molecules regulate the navigation of retinal ganglion cell (RGC) projections toward targets in the visual thalamus. In this study, we demonstrate that the G-protein-coupled receptor 55 (GPR55) is expressed in the retina during development, and ...
Hosni Cherif +8 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Ultrathin, flexible neural probes are developed with an innovative, biomimetic design incorporating brain tissue‐compatible materials. The material system employs biomolecule‐based encapsulation agents to mitigate inflammatory responses, as demonstrated through comprehensive in vitro and in vivo studies.
Jeonghwa Jeong +7 more
wiley +1 more source
Neural Development, 2009 Background While many molecules involved in axon guidance have been identified, the cellular and molecular mechanisms by which these molecules regulate growth cone morphology during axon outgrowth remain to be elucidated.
Lundquist Erik A +2 more
doaj +1 more source
Neuron Growth Control by PDE Backstepping: Axon Length Regulation by Tubulin Flux Actuation in Soma [PDF]
arXiv, 2021 In this work, stabilization of an axonal growth in a neuron associated with the dynamics of tubulin concentration is proposed by designing a boundary control. The dynamics are given by a parabolic Partial Differential Equation (PDE) of the tubulin concentration, with a spatial domain of the axon's length governed by an Ordinary Differential Equation ...
arxiv
Neural Development, 2015 BackgroundRac1 is a critical regulator of cytoskeletal dynamics in multiple cell types. In the nervous system, it has been implicated in the control of cell proliferation, neuronal migration, and axon development.ResultsTo systematically investigate the ...
Zhong L. Hua +2 more
semanticscholar +1 more source
The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches
Cell Reports, 2019 Summary: In developing neurons, phosphoinositide 3-kinases (PI3Ks) control axon growth and branching by positively regulating PI3K/PI(3,4,5)P3, but how neurons are able to generate sufficient PI(3,4,5)P3 in the presence of high levels of the antagonizing
Annika Brosig +19 more
doaj
Retrograde Ret signaling controls sensory pioneer axon outgrowth
eLife, 2019 The trafficking mechanisms and transcriptional targets downstream of long-range neurotrophic factor ligand/receptor signaling that promote axon growth are incompletely understood. Zebrafish carrying a null mutation in a neurotrophic factor receptor, Ret,
Adam Tuttle +4 more
doaj +1 more source
Mechanisms of Axon Elongation Following CNS Injury: What Is Happening at the Axon Tip?
Frontiers in Cellular Neuroscience, 2020 After an injury to the central nervous system (CNS), functional recovery is limited by the inability of severed axons to regenerate and form functional connections with appropriate target neurons beyond the injury.
William Rodemer +4 more
doaj +1 more source