Results 91 to 100 of about 56,490 (282)

Bioactive Conductive Ti3C2Tx‐Ce Hydrogel Facilitates Spinal Cord Injury Repair Through ROS Scavenging and Mitochondrial Regulation

Advanced Functional Materials, EarlyView.
Bioactive conductive Ti3C2Tx‐Ce hydrogels with with scavenging ROS and alleviating neuronal mitochondrial dysfunction are exploited for SCI treatment. This functionality is attributed to interfacial activation modification of Ti3C2Tx with Ce3+ ions to in‐situ form Ce(OH)x‐mediated protective layer, which is beneficial to enabling stable intracellular ...
Weikang Wang, Qing Liu, Ang Lv, Yabin Lin, Jiawei Chen, Ning Ding, Chunlei Zhang, Shuai Zhou, Bo Yuan, Weiwei Zhao, Liming Li, Luping Zhang, Fei Huang   +12 more
wiley   +1 more source

Modeling of interstitial branching of axonal networks [PDF]

, 2013
A single axon can generate branches connecting with plenty synaptic targets. Process of branching is very important for making connections in central nervous system.
Gafarov, F., Khusnutdinov, N., Suleymanov, Y.   +2 more
core   +2 more sources

FGF14 localization and organization of the axon initial segment [PDF]

Molecular and Cellular Neuroscience, 2013
The axon initial segment (AIS) is highly enriched in the structural proteins ankyrin G and βIV-spectrin, the pore-forming (α) subunits of voltage-gated sodium (Nav) channels, and functional Nav channels, and is critical for the initiation of action potentials.
Maolei, Xiao, Marie K, Bosch, Jeanne M, Nerbonne, David M, Ornitz   +3 more
openaire   +2 more sources

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment

Cell Reports, 2017
Neuronal chloride levels are developmentally regulated. Early in life, high intracellular concentrations support chloride efflux and depolarization at GABAergic synapses.
Gina Rinetti-Vargas, Khanhky Phamluong, Dorit Ron, Kevin J. Bender   +3 more
doaj   +1 more source

Automated optimization of a reduced layer 5 pyramidal cell model based on experimental data. [PDF]

, 2012
The construction of compartmental models of neurons involves tuning a set of parameters to make the model neuron behave as realistically as possible.
Bahl, A, Herz, AV, Roth, A, Stemmler, MB
core   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Hippocampal Chandelier Cells Modulate Seizure Susceptibility and Severity

Advanced Science
The axon initial segment (AIS), serving as the site for initiating action potentials (APs), is a key target for efficient regulation of neuronal activity.
Yang Li, Jifeng Tian, Jiafan Wei, Qianyun Wang, Jiaxu Ge, Jianguang Ni, Jiangteng Lu, Yilin Tai   +7 more
doaj   +1 more source

IκBα is not required for axon initial segment assembly [PDF]

Molecular and Cellular Neuroscience, 2012
The inhibitor of NF-κB alpha (IκBα) protein is an important regulator of the transcription factor NF-κB. In neurons, IκBα has been shown to play a role in neurite outgrowth and cell survival. Recently, a phosphorylated form of IκBα (pIκBα Ser32/36) was reported to be highly enriched at the axon initial segment (AIS) and was proposed to function ...
Shelly A, Buffington, Jürgen M, Sobotzik, Christian, Schultz, Matthew N, Rasband   +3 more
openaire   +2 more sources

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source