Results 111 to 120 of about 29,685 (270)
Neuron Morphology Influences Axon Initial Segment Plasticity
, 2016 In most vertebrate neurons, action potentials are initiated in the axon initial segment (AIS), a specialized region of the axon containing a high density of voltage-gated sodium and potassium channels.
Gulledge, Allan T, Bravo, Jaime J
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Rapid Modulation of Axon Initial Segment Length Influences Repetitive Spike Firing
Cell Reports, 2015 Neurons implement a variety of plasticity mechanisms to alter their function over timescales ranging from seconds to days. One powerful means of controlling excitability is to directly modulate the site of spike initiation, the axon initial segment (AIS).
Mark D. Evans +4 more
doaj +1 more source
Traction Force Microscopy for Viscoelastic Substrates: A Semi‐Analytical Method
Advanced Science, EarlyView.A semi‐analytical viscoelastic traction force microscopy framework is introduced for quantifying time‐resolved cell tractions on flat finite‐thickness substrates. The method generalizes elastic traction force microscopy to Generalized Maxwell materials, identifies when elastic approximations remain valid and, when they do not, shows that inferred ...
Adrià Villacrosa‐Ribas +10 more
wiley +1 more source
Alternative Splicing Control of Trim46 Regulates Formation of the Axon Initial Segment [PDF]
, 2020 Alternative splicing produces mRNA isoforms of distinct structure and function from the same gene. Neuronal polarization has been shown to be regulated by alternative splicing in the brain.
Vuong, John K
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LONGITUDINAL ACTIN FILAMENTS IN THE AXON INITIAL SEGMENT
IBRO Neuroscience Reports, 2023 David Micinski, Pirta Hotulainen
doaj +1 more source
Plasticity of GABAA receptor diffusion dynamics at the axon initial segment
Frontiers in Cellular Neuroscience, 2014 The axon initial segment (AIS), a site of action potential initiation, undergoes activity-dependent homeostatic repositioning to fine-tune neuronal activity.
James eMuir, Josef eKittler
doaj +1 more source
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
The Axon Initial Segment, 50 Years Later: A Nexus for Neuronal Organization and Function
, 2016 International audienceThe axon initial segment is a highly specialized neuronal compartment, identified almost 50years ago by the pioneers of electron microscopy.
Leterrier, Christophe +1 more
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Advanced Science, EarlyView.ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv +8 more
wiley +1 more source
Phosphorylated IkappaBα is highly enriched in the axon initial segment
, 2004 The transcription factor NF-KappaB (NF-KB) is present in the cytosol in an inactive state, complexed with the inhibitory protein IKappaBα. Constitutive activation of NF-KB occurs in neurons of the central nervous system via phosphorylation of IKappaBα at
Del Turco, D. +7 more
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