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The Physiology of the Axon Initial Segment
Annual Review of Neuroscience, 2012The action potential generally begins in the axon initial segment (AIS), a principle confirmed by 60 years of research; however, the most recent advances have shown that a very rich biology underlies this simple observation. The AIS has a remarkably complex molecular composition, with a wide variety of ion channels and attendant mechanisms for channel ...
Kevin J, Bender, Laurence O, Trussell
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Consciousness and the Axon Initial Segment
Integrative Psychological and Behavioral ScienceAccording to the QBIT theory, consciousness depends on the emergence of macroscopic coherence in a specific intracellular substrate which registers and processes sensory information. This occurs in a particular neuronal compartment called the axon initial segment which has unique properties not found in other neuronal segments.
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The latest on the axon initial segment
2018 7th International Conference on Computers Communications and Control (ICCCC), 2018This paper will review the latest results about the axon initial segment (AIS) revealing physiology details while focusing on the structural organization of the AIS. This highly specialized region of the axon is characterized, among others, by high concentrations of (particular) voltage-gated ion channels, and by highly specialized cytoskeletal ...
Roxana-Mariana Beiu +2 more
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Cilia function is associated with axon initial segment morphology
Biochemical and Biophysical Research Communications, 2019Cilia, as key integrators of extracellular ligand-based signaling, play a critical role in signaling in the neuronal system. However, the function of cilia in neurons is largely unknown. In this study, we discovered that cilia morphology and ciliary protein localization were associated with axon initial segment (AIS) morphology, including length and ...
Bingjie Wang +3 more
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Action Potential Initiation in a Damaged Axon Initial Segment
2016We constructed a model for the initiation of the action potential (AP) in a damaged axon initial segment(AIS). We modelled the full axon including the AIS with a system of partial differential equations that we solved numerically. The damage was modelled on the AIS by having selected voltage-gated sodium channels affected by a coupled left-shift (CLS ...
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Astrocyte scar formation aids central nervous system axon regeneration
Nature, 2016Mark A Anderson +2 more
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Programmed axon degeneration: from mouse to mechanism to medicine
Nature Reviews Neuroscience, 2020Michael P Coleman, Ahmet Hoke
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