The axonal cytoskeleton: from organization to function [PDF]
Frontiers in Molecular Neuroscience, 2015 The axon is the single long fiber that extends from the neuron and transmits electrical signals away from the cell body. The neuronal cytoskeleton, composed of microtubules, actin filaments and neurofilaments, is not only required for axon formation and ...
Josta eKevenaar, Casper eHoogenraad
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Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration [PDF]
Neurobiology of Disease, 2013 In both the central nervous system (CNS) and peripheral nervous system (PNS), transected axons undergo Wallerian degeneration. Even though Augustus Waller first described this process after transection of axons in 1850, the molecular mechanisms may be ...
Marek Ma +7 more
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Stabilization of neuronal connections and the axonal cytoskeleton. [PDF]
Bioarchitecture, 2014 Stabilization of axonal connections is an underappreciated, but critical, element in development and maintenance of neuronal functions. The ability to maintain the overall architecture of the brain for decades is essential for our ability to process sensory information efficiently, coordinate motor activity, and retain memories for a lifetime.
Song Y, Brady ST.
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Coordination of the axonal cytoskeleton during the emergence of axon collateral branches.
Neural Regen Res, 2016 The formation of branches during development allows a single axon to make synaptic contacts with numerous target neurons, often in different parts of the nervous system, thereby allowing for the establishment of complex patterns of neuronal connectivity.
Gallo G.
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A critical reevaluation of the stationary axonal cytoskeleton hypothesis. [PDF]
Cytoskeleton (Hoboken), 2013 AbstractNeurofilaments are transported along axons in a rapid intermittent and bidirectional manner but there is a long‐standing controversy about whether this applies to all axonal neurofilaments. Some have proposed that only a small proportion of axonal neurofilaments are mobile and that most are deposited into a persistently stationary and ...
Brown A, Jung P.
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Cytoskeleton and Membrane Organization at Axon Branches [PDF]
Frontiers in Cell and Developmental Biology, 2021 Axon branching is a critical process ensuring a high degree of interconnectivity for neural network formation. As branching occurs at sites distant from the soma, it is necessary that axons have a local system to dynamically control and regulate axonal ...
Satish Bodakuntla +4 more
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The nano-architecture of the axonal cytoskeleton [PDF]
Nature Reviews Neuroscience, 2017 The corporeal beauty of the neuronal cytoskeleton has captured the imagination of generations of scientists. One of the easiest cellular structures to visualize by light microscopy, its existence has been known for well over 100 years, yet we have only recently begun to fully appreciate its intricacy and diversity.
Christophe Leterrier +2 more
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A Distal Axonal Cytoskeleton Forms an Intra-Axonal Boundary that Controls Axon Initial Segment Assembly [PDF]
Cell, 2012 AnkyrinG (ankG) is highly enriched in neurons at axon initial segments (AISs) where it clusters Na(+) and K(+) channels and maintains neuronal polarity. How ankG becomes concentrated at the AIS is unknown. Here, we show that as neurons break symmetry, they assemble a distal axonal submembranous cytoskeleton, comprised of ankyrinB (ankB), αII-spectrin ...
Mauricio R. Galiano +8 more
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JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton. [PDF]
Commun Biol, 2022 Rafiq NM +4 more
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Reflectance Spectrum and Birefringence of the Retinal Nerve Fiber Layer With Hypertensive Damage of Axonal Cytoskeleton. [PDF]
Invest Ophthalmol Vis Sci, 2017 Huang XR +5 more
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