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The axonal cytoskeleton: from organization to function [PDF]
Frontiers in Molecular Neuroscience, 2015 The axon is the single long fiber that extends from the neuron and transmits electrical signals away from the cell body. The neuronal cytoskeleton, composed of microtubules, actin filaments and neurofilaments, is not only required for axon formation and ...
Josta eKevenaar, Casper eHoogenraad
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Stabilization of neuronal connections and the axonal cytoskeleton. [PDF]
Bioarchitecture, 2014 Stabilization of axonal connections is an underappreciated, but critical, element in development and maintenance of neuronal functions. The ability to maintain the overall architecture of the brain for decades is essential for our ability to process sensory information efficiently, coordinate motor activity, and retain memories for a lifetime.
Song Y, Brady ST.
europepmc +8 more sources
The Axonal Cytoskeleton and the Assembly of Nodes of Ranvier. [PDF]
Neuroscientist, 2018 Vertebrate nervous systems rely on rapid nerve impulse transmission to support their complex functions. Fast conduction depends on ensheathment of nerve axons by myelin-forming glia and the clustering of high concentrations of voltage-gated sodium channels (Nav) in the axonal gaps between myelinated segments.
Ghosh A, Sherman DL, Brophy PJ.
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Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration [PDF]
Neurobiology of Disease, 2013 In both the central nervous system (CNS) and peripheral nervous system (PNS), transected axons undergo Wallerian degeneration. Even though Augustus Waller first described this process after transection of axons in 1850, the molecular mechanisms may be ...
Marek Ma +7 more
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Coordination of the axonal cytoskeleton during the emergence of axon collateral branches.
Neural Regen Res, 2016 The formation of branches during development allows a single axon to make synaptic contacts with numerous target neurons, often in different parts of the nervous system, thereby allowing for the establishment of complex patterns of neuronal connectivity.
Gallo G.
europepmc +7 more sources
A critical reevaluation of the stationary axonal cytoskeleton hypothesis. [PDF]
Cytoskeleton (Hoboken), 2013 AbstractNeurofilaments are transported along axons in a rapid intermittent and bidirectional manner but there is a long‐standing controversy about whether this applies to all axonal neurofilaments. Some have proposed that only a small proportion of axonal neurofilaments are mobile and that most are deposited into a persistently stationary and ...
Brown A, Jung P.
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JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton. [PDF]
Commun Biol, 2022 Lysosome axonal transport is important for the clearance of cargoes sequestered by the endocytic and autophagic pathways. Building on observations that mutations in the JIP3 ( MAPK8IP3 ) gene result in lysosome-filled axonal swellings, we analyzed the ...
Rafiq NM +4 more
europepmc +4 more sources
The nano-architecture of the axonal cytoskeleton [PDF]
Nature Reviews Neuroscience, 2017 The corporeal beauty of the neuronal cytoskeleton has captured the imagination of generations of scientists. One of the easiest cellular structures to visualize by light microscopy, its existence has been known for well over 100 years, yet we have only recently begun to fully appreciate its intricacy and diversity.
Christophe Leterrier +2 more
semanticscholar +7 more sources
Distortion of axonal cytoskeleton: an early sign of glaucomatous damage. [PDF]
Invest Ophthalmol Vis Sci, 2011 PURPOSE Glaucoma damages the retinal nerve fiber layer (RNFL). The purpose of this study was to investigate the distribution of major cytoskeleton components, F-actin, microtubules (MTs), and neurofilaments (NFs), in the RNFL during the development of ...
Huang X, Kong W, Zhou Y, Gregori G.
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Reflectance Spectrum and Birefringence of the Retinal Nerve Fiber Layer With Hypertensive Damage of Axonal Cytoskeleton. [PDF]
Invest Ophthalmol Vis Sci, 2017 Purpose Glaucoma damages the retinal nerve fiber layer (RNFL). This study used precise multimodal image registration to investigate the changes of the RNFL reflectance spectrum and birefringence in nerve fiber bundles with different degrees of axonal ...
Huang XR +5 more
europepmc +4 more sources